Patents Assigned to Hexachimie
  • Patent number: 4595686
    Abstract: A novel compound of formula: ##STR1## useful as analgesic and anti-inflammatory drug, with very interesting therapeutic index.
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: June 17, 1986
    Assignee: Hexachimie
    Inventors: Nicole Bru-Magniez, Jean-Marie Teulon, Romano Deghenghi
  • Patent number: 4271161
    Abstract: Compounds of the formula: ##STR1## in which R represents an ethyl or isopropyl group, and their addition salts with acids or quaternary ammonium salts can be prepared from the compounds: ##STR2## in which R has the same meaning as above, and are valuable as analgesics.
    Type: Grant
    Filed: July 9, 1979
    Date of Patent: June 2, 1981
    Assignee: Hexachimie
    Inventor: Jean M. Teulon
  • Patent number: 4234742
    Abstract: Compounds of the formula: ##STR1## in which A is a methylene group, sulphur or a disulphide bridge, R is a hydrogen atom or a methyl group, R.sub.1 is a linear or branched alkyl group having 1 to 4 carbon atoms, and R.sub.2 is an alkyl group having 1 to 4 carbon atoms, or a halogen atom, or an alkoxy group, and their pharmaceutically acceptable salts have a valuable hypocholesterolemia-inducing activity.
    Type: Grant
    Filed: June 5, 1979
    Date of Patent: November 18, 1980
    Assignee: Hexachimie
    Inventors: Jean C. Cognacq, Jean Lacrampe
  • Patent number: 4163785
    Abstract: The invention relates to 5-piperazinyl pyrido-[2,3-b][1,5] benzothiazepines of Formula I ##STR1## in which R is a hydrogen atom or a C.sub.1-5 alkyl group and their non-toxic acid addition salts. These compounds have antihistamine and antianaphylaxic activity. The invention also relates to a method of preparing these compounds.
    Type: Grant
    Filed: April 3, 1978
    Date of Patent: August 7, 1979
    Assignee: Hexachimie
    Inventors: Charles Hoffmann, Etienne Bouley
  • Patent number: 4156009
    Abstract: The invention relates to 6-cyclopropyl-1,3-dihydro-1-methyl-5-phenyl-2-oxo-2H-thieno [2,3-e] diazepine and pharmaceutically acceptable non-toxic acid addition salts, these compounds being useful as medicaments particularly for the treatment of gastro-duodenyl disorders. A synthesis for the diazepine is also described.
    Type: Grant
    Filed: March 27, 1978
    Date of Patent: May 22, 1979
    Assignee: Hexachimie
    Inventor: Jean-Claude Cognacq
  • Patent number: 4156000
    Abstract: Cyclopenta[b]thiophene derivatives of formula: ##STR1## in which R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3 is hydrogen, lower alkyl, or aminoalkyl, and their salts are useful in therapy particularly as analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: July 31, 1978
    Date of Patent: May 22, 1979
    Assignee: Hexachimie
    Inventor: Jean-Marie Teulon
  • Patent number: 4152434
    Abstract: Morpholine derivatives of the formula: ##STR1## in which Z is CH or N, Y is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, R is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, benzyl, or phenyl, and R.sub.1 is hydrogen or benzyl, and their non-toxic pharmaceutically acceptable acid addition salts have interesting therapeutic properties, especially on the central nervous system.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: May 1, 1979
    Assignee: Hexachimie
    Inventor: Bernard Schwiesguth
  • Patent number: 4122175
    Abstract: Morpholine derivatives of the formula: ##STR1## in which Z is CH or N, Y is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, R is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, benzyl, or phenyl, and R.sub.1 is hydrogen or benzyl, and their non-toxic pharmaceutically acceptable acid addition salts have interesting therapeutic properties, especially on the central nervous system.
    Type: Grant
    Filed: April 21, 1977
    Date of Patent: October 24, 1978
    Assignee: Hexachimie
    Inventor: Bernard Schweisguth
  • Patent number: 4122091
    Abstract: Cyclopenta[b]thiophene derivatives of formula: ##STR1## in which R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3 is hydrogen, lower alkyl, or aminoalkyl, and their salts are useful in therapy particularly as analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: March 8, 1977
    Date of Patent: October 24, 1978
    Assignee: Hexachimie
    Inventor: Jean-Marie Teulon
  • Patent number: 4109008
    Abstract: The invention provides novel hydrazine derivatives of the formula: ##STR1## in which R is a variously substituted oxy or thio substituted phenyl radical, 2-oxobenzimidazol-5-yl radical or 3-pyridyl radical;R' is a radical of formula: ##STR2## in which R.sub.5 and R.sub.6 taken separately are each hydrogen, and taken together form, with the nitrogen atoms to which they are attached, an imidazolinyl radical of formula; ##STR3## and R" is hydrogen or lower alkyl, and the pharmaceutically acceptable addition salts, with non-toxic acids, of these hydrazine derivatives.These compounds are useful as anti-hypertensive agents.
    Type: Grant
    Filed: December 29, 1976
    Date of Patent: August 22, 1978
    Assignee: Hexachimie
    Inventors: Jean-Calude Cognacq, Bernard Schweisguth, Jean-Marie Teulon