Abstract: Compounds of the formula: ##STR1## in which R represents an ethyl or isopropyl group, and their addition salts with acids or quaternary ammonium salts can be prepared from the compounds: ##STR2## in which R has the same meaning as above, and are valuable as analgesics.
Abstract: Compounds of the formula: ##STR1## in which A is a methylene group, sulphur or a disulphide bridge, R is a hydrogen atom or a methyl group, R.sub.1 is a linear or branched alkyl group having 1 to 4 carbon atoms, and R.sub.2 is an alkyl group having 1 to 4 carbon atoms, or a halogen atom, or an alkoxy group, and their pharmaceutically acceptable salts have a valuable hypocholesterolemia-inducing activity.
Abstract: The invention relates to 5-piperazinyl pyrido-[2,3-b][1,5] benzothiazepines of Formula I ##STR1## in which R is a hydrogen atom or a C.sub.1-5 alkyl group and their non-toxic acid addition salts. These compounds have antihistamine and antianaphylaxic activity. The invention also relates to a method of preparing these compounds.
Abstract: The invention relates to 6-cyclopropyl-1,3-dihydro-1-methyl-5-phenyl-2-oxo-2H-thieno [2,3-e] diazepine and pharmaceutically acceptable non-toxic acid addition salts, these compounds being useful as medicaments particularly for the treatment of gastro-duodenyl disorders. A synthesis for the diazepine is also described.
Abstract: Cyclopenta[b]thiophene derivatives of formula: ##STR1## in which R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3 is hydrogen, lower alkyl, or aminoalkyl, and their salts are useful in therapy particularly as analgesic and anti-inflammatory agents.
Abstract: Morpholine derivatives of the formula: ##STR1## in which Z is CH or N, Y is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, R is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, benzyl, or phenyl, and R.sub.1 is hydrogen or benzyl, and their non-toxic pharmaceutically acceptable acid addition salts have interesting therapeutic properties, especially on the central nervous system.
Abstract: Morpholine derivatives of the formula: ##STR1## in which Z is CH or N, Y is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, R is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, benzyl, or phenyl, and R.sub.1 is hydrogen or benzyl, and their non-toxic pharmaceutically acceptable acid addition salts have interesting therapeutic properties, especially on the central nervous system.
Abstract: Cyclopenta[b]thiophene derivatives of formula: ##STR1## in which R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3 is hydrogen, lower alkyl, or aminoalkyl, and their salts are useful in therapy particularly as analgesic and anti-inflammatory agents.
Abstract: The invention provides novel hydrazine derivatives of the formula: ##STR1## in which R is a variously substituted oxy or thio substituted phenyl radical, 2-oxobenzimidazol-5-yl radical or 3-pyridyl radical;R' is a radical of formula: ##STR2## in which R.sub.5 and R.sub.6 taken separately are each hydrogen, and taken together form, with the nitrogen atoms to which they are attached, an imidazolinyl radical of formula; ##STR3## and R" is hydrogen or lower alkyl, and the pharmaceutically acceptable addition salts, with non-toxic acids, of these hydrazine derivatives.These compounds are useful as anti-hypertensive agents.
Type:
Grant
Filed:
December 29, 1976
Date of Patent:
August 22, 1978
Assignee:
Hexachimie
Inventors:
Jean-Calude Cognacq, Bernard Schweisguth, Jean-Marie Teulon