Abstract: The present invention refers to compositions comprising a LH-RH-analogue and/or pharmaceutically acceptable salts thereof in a low-dose and a degradation-resistant polylactide suitable for the preparation of subcutaneous implants. Sterilization of the polylactide via gamma-radiation as well as temperature stress result in a negligible decomposition of less than 1000 Dalton.
Type:
Grant
Filed:
March 20, 2007
Date of Patent:
December 27, 2011
Assignee:
Hexel AG
Inventors:
Anna Sendl-Lang, Kai-Thomas Kramer, Gregor Schütz