Abstract: Peptides and pharmaceutically acceptable salts thereof of the following formula are provided ##STR1## wherein R is selected from the group consisting of Leu, Ile and Val,X is from zero to four amino acids,Y is from zero to four amino acids, andZ is OH or NH.sub.2.The compounds are useful in inhibiting thrombin- and plasmin-induced aggregation of human platelets.
Type:
Grant
Filed:
April 11, 1994
Date of Patent:
June 27, 1995
Assignees:
Rei Matsueda, Hideaki Umeyama
Inventors:
Robert W. Colman, Rajinder N. Puri, Rei Matsueda, Hideaka Umeyama