Abstract: Object: To provide a cyclic hexapeptide compound having a distinguished pharmaceutical effect.Constitution: A cyclic hexapeptide compound represented by the following formula: ##STR1## where R is a group represented by the following formula: ##STR2## (where R.sup.1 and R.sup.2 are each an alkyl group, a phenyl group or a benzyl group) or a group represented by the following formula: ##STR3## (where n is an integer of 4 to 6), or its salts.