Patents Assigned to Hidex Oy
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Patent number: 12123989Abstract: The present invention provides a method for determining a background count rate in liquid scintillation counting. The method comprises measuring external standard spectra of a sample, determining, from the external standard spectra, a triple to double coincidence ratio and a quench parameter, determining, based on the triple to double coincidence ratio and the quench parameter, a background reference parameter, and determining, based on the background reference parameter, the background count rate from a background reference curve.Type: GrantFiled: March 16, 2022Date of Patent: October 22, 2024Assignee: Hidex OyInventors: Petri Aronkytö, Eveliina Arponen, Ville Haaslahti, Risto Juvonen, Timo Oikari
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Patent number: 11520058Abstract: The present invention provides a method for determining a background count rate in liquid scintillation counting. The method comprises measuring an external standard spectrum (201, 202) of a sample, determining, from the external standard spectrum, an external standard count rate within an energy window (203), determining, based on the external standard count rate within the energy window, a background reference parameter, and determining, based on the background reference parameter, the background count rate from a background reference curve (301).Type: GrantFiled: May 10, 2021Date of Patent: December 6, 2022Assignee: Hidex OyInventors: Petri Aronkyto, Eveliina Arponen, Ville Haaslahti, Risto Juvonen, Timo Oikari
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Publication number: 20210389478Abstract: The present invention provides a method for determining a background count rate in liquid scintillation counting. The method comprises measuring an external standard spectrum (201, 202) of a sample, determining, from the external standard spectrum, an external standard count rate within an energy window (203), determining, based on the external standard count rate within the energy window, a background reference parameter, and determining, based on the background reference parameter, the background count rate from a background reference curve (301).Type: ApplicationFiled: May 10, 2021Publication date: December 16, 2021Applicant: Hidex OyInventors: Petri ARONKYTO, Eveliina ARPONEN, Ville HAASLAHTI, Risto JUVONEN, Timo OIKARI
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Patent number: 8182988Abstract: A homogenous bioassay including i) a first group containing a short lifetime fluorescent acceptor, and ii) a second group containing a quencher, with the first and second groups linked by at least a first linkage. The bioassay measures the acceptor's fluorescence increase resulting from cleavage of the first linkage and also includes iii) a third group containing a donor for energy transfer to the acceptor, where the donor is an up-conversion fluorescent compound, a long-lifetime fluorescent compound or an electrogenerated luminescent compound. A conformational or terminal epitope is created on the first group through linkage cleavage, and the third group includes a binder with affinity for this epitope. The acceptor's fluorescence is caused by exciting the donor. Also disclosed are bioassay kits for this method.Type: GrantFiled: February 26, 2008Date of Patent: May 22, 2012Assignee: Hidex OyInventors: Tero Soukka, Urpo Lamminmäki
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Patent number: 7826052Abstract: A method to correct measurement error in a resonance energy-transfer assay, including exciting anti-Stokes photoluminescent donors with at least one wavelength of light which is greater than an emission wavelength of acceptor molecules; measuring emission at the acceptor's emission wavelength and which differs from the donor's emission wavelength in at least two different time windows; a first time window within the time window defined by the excitation light pulse and a second non-overlapping time window which follows the first time window; and correcting the emission signal, which includes signals originating from non-radiative and radiative energy transfer, within the first time window by estimating the ratio of the signals from non-radiative and radiative energy transfer or the signal originating from radiative energy transfer using at least one emission signal measured in the second time window.Type: GrantFiled: May 24, 2006Date of Patent: November 2, 2010Assignee: Hidex OyInventors: Ville Haaslahti, Juhani Aalto, Timo Oikari, Tero Soukka
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Patent number: 7790392Abstract: A homogenous bioassay including a first group including an acceptor which is a short lifetime fluorescent compound capable of energy transfer, and a second group including a quencher which is capable of energy transfer from an acceptor. The increase or decrease of the acceptor's fluorescence resulting from lengthening or shortening of the distance between the acceptor and quencher is measured. The bioassay also includes a third group including a donor for energy transfer to the acceptor, which donor is an up-conversion fluorescent compound, a long-lifetime fluorescent compound or an electrogenerated luminescent compound. The first group includes a tag, the third group includes a binder having a high affinity for binding to the tag. Fluorescence of the acceptor is brought about by exciting the donor resulting in energy being transferred from the donor to the acceptor.Type: GrantFiled: November 17, 2006Date of Patent: September 7, 2010Assignee: Hidex OyInventors: Tero Soukka, Timo Oikari, Ville Haaslahti
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Publication number: 20090324493Abstract: The invention relates to a method for preparing a saline solution comprising [13N]NH4+. The method comprises following steps: preparing [13N]NH3 gas, transporting [13N]NH3 gas to a diffusion chamber, to a first side of a semipermeable membrane, transporting sterile saline solution to the diffusion chamber, to a second side of a semipermeable membrane, allowing the mixing of [13N]NH3 gas that has penetrated the semipermeable membrane with the saline solution on the second side of the semipermeable membrane, whereby saline solution comprising [13N]NH4+ is obtained, and directing the saline solution comprising [13N]NH4+ out from the diffusion chamber. The invention relates also to use of a device for preparing a radiolabelled saline solution for preparation of a saline solution comprising [13N]NH4+.Type: ApplicationFiled: April 25, 2006Publication date: December 31, 2009Applicant: HIDEX OYInventors: Paul Burke, Hannu Sipilä, John Charles Clark
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Patent number: 6858187Abstract: A device for preparing a radioactive water solution to be infused in a patient includes a reaction chamber (13) in which radioactive water vapour is formed by the catalysed reaction of oxygen gas containing oxygen-15 and hydrogen gas. A diffusion chamber (14) is provided which allows the radioactive water to penetrate, but which prevents the penetration of gasses. Tubes (26) and valves (16, 18) direct a sterile saline solution to the diffusion chamber (14), and then direct the saline solution containing radioactive water out from the diffusion chamber to a patient, or to a decay coil (22) being a part of the device. A measuring instrument is provided for measuring the radioactivity of the radioactive solution. The device is characterized in that the diffusion chamber (14), the tubes (26) the valves (16, 18), the radioactivity measuring instrument (17), and preferably also the reaction chamber 913), are mounted in the same frame 50, whereby they form a separate unit i.e.Type: GrantFiled: May 9, 2000Date of Patent: February 22, 2005Assignees: Hidex Oy, Oy Fluorplast ABInventors: Hannu Sipila, John Clark, Tom Wickstrom, Henri Tochon-Danguy
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Patent number: D744498Type: GrantFiled: October 8, 2013Date of Patent: December 1, 2015Assignee: Hidex OyInventors: Niklas Ekholm, Teemu Suviala, Ville Haaslahti
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Patent number: D757098Type: GrantFiled: July 21, 2015Date of Patent: May 24, 2016Assignee: Hidex OyInventors: Niklas Ekholm, Teamu Suviala, Ville Haaslahti