Abstract: A method of synthesizing deuterated morphine-3.beta.-glucuronide, morphine-6.beta.-glucuronide, and codeine-6.beta.-glucuronide is disclosed. The chemicals are used as internal standards for mass spectrometry analyses of morphine, heroin, and codeine uses. They are also useful in the study of metabolism of morphine and codeine.
Type:
Grant
Filed:
May 12, 1997
Date of Patent:
June 1, 1999
Assignee:
High Standard Products Corporation
Inventors:
Hoa Duc Nguyen, Duc Tien Nguyen, Raymond Albert Schep, Trinh Duc Nguyen, Phuong Thi Ngoc Pham