Abstract: An irinotecan liposome preparation, a preparation method, and use thereof. The irinotecan liposome includes: irinotecan, a liposome carrier, an internal aqueous phase located inside a liposome membrane and an external aqueous phase located outside the liposome membrane, the irinotecan being encapsulated in the internal aqueous phase; a sulfonate gradient exists between the internal aqueous phases inside the liposome membrane and the external aqueous phase outside the liposome membrane. The liposome takes monovalent sulfonate and disulfonate as the internal aqueous phases, encapsulates the irinotecan in the internal aqueous phases of the liposome in the form of insoluble sulfonate or disulfonate, and has a good sustained-release effect.

Abstract: The present disclosure provides an all-trans retinoic acid injectable formulation and its application for a preparation of a pharmaceutical product for treating tumor. The all-trans retinoic acid injectable formulation includes all-trans retinoic acid and solubilizers. The apparent solubility of the all-trans retinoic acid is increased from 0.01 mg/mL to 0.1 mg/mL or more. The injectable formulation can reduce the activity of an infiltrated immuno-suppressive cell population within blood or tumor tissue of a cancer patient, and improve immune clearing effects against tumors. It can be applied independently or together with other pharmaceutical products to inhibit tumor growth and prevent tumor recurrence.

Abstract: The present disclosure provides an all-trans retinoic acid injectable formulation and its application for a preparation of a pharmaceutical product for treating tumor. The all-trans retinoic acid injectable formulation includes all-trans retinoic acid and solubilizers. The apparent solubility of the all-trans retinoic acid is increased from 0.01 mg/mL to 0.1 mg/mL or more. The injectable formulation can reduce the activity of an infiltrated immuno-suppressive cell population within blood or tumor tissue of a cancer patient, and improve immune clearing effects against tumors. It can be applied independently or together with other pharmaceutical products to inhibit tumor growth and prevent tumor recurrence.