Patents Assigned to Hikal Limited
-
Publication number: 20230250069Abstract: The present invention relates to an industrial scale process for the preparation of Prothioconazole (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and greater chemical purity.Type: ApplicationFiled: October 5, 2020Publication date: August 10, 2023Applicant: Hikal LimitedInventors: Sudhir NAMBIAR, Santosh GHOSH, Nagaprasada Rao L., Pramod SAWANT, Vinayak LAMBATE, Dnyaneshwar NIPUNGE, Somwanshi ATUL
-
Publication number: 20230250124Abstract: The present invention relates to substantially pure Clarithromycin 9-oxime more particularly Clarithromycin 9(E)-oxime having purity more than 98% and corresponding (Z)-isomer not more than 1%. The present invention further relates to a process for preparation of Clarithromycin 9(E)-oxime of formula (I), its pharmaceutically acceptable salts and purification.Type: ApplicationFiled: October 27, 2020Publication date: August 10, 2023Applicants: HIKAL LIMITED, GALAPAGOSInventors: Sudhir NAMBIAR, Rakesh Ramesh GANORKAR, Kiran CHAUDHARI, Anil GOHAR, Deeksha SINGH, Patrick CLAERHOUT STIJN POL
-
Patent number: 11649204Abstract: The present invention relates to an improved process for the preparation of trifloxystrobin of formula (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and chemical purity.Type: GrantFiled: August 30, 2018Date of Patent: May 16, 2023Assignee: Hikal LimitedInventors: Kamlesh Kantilal Lodha, Sandip Popatrao Udawant, Deepak Babasaheb Phasage, Lakonda Nagaprasada Rao, Santosh Kumar Ghosh, Sudhir Nambiar
-
Publication number: 20220389040Abstract: The present invention relates to a process for resolution of Chlocyphos of Formula (I) to obtain corresponding (S)- or (R)-isomers. The present invention further relates to a process of obtaining (S)-Chlocyphos using (R)-(+)-?-methylbenzylamine and (R)-Chlocyphos using (S)-?-methylbenzylamine. The said resolution process provides the corresponding isomer with chiral purity more than 98%.Type: ApplicationFiled: October 13, 2020Publication date: December 8, 2022Applicant: Hikal LimitedInventors: Rakesh Ramesh GANORKAR, Sudhir NAMBIAR, Narayan Subhash CHAKOR, H.D. GURUPADASWAMY, Shamrao Bapurao SHELAR
-
Publication number: 20200283373Abstract: The present invention relates to an improved process for the preparation of trifloxystrobin of formula (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and chemical purity.Type: ApplicationFiled: August 30, 2018Publication date: September 10, 2020Applicant: HIKAL LIMITEDInventors: Kamlesh Kantilal LODHA, Sandip Popatrao UDAWANT, Deepak Babasaheb PHASAGE, Lakonda Nagaprasada RAO, Santosh Kumar GHOSH, Sudhir NAMBIAR
-
Patent number: 10544101Abstract: The present invention relates to an improved process for the preparation of Butorphanol tartrate of formula (I),Type: GrantFiled: March 27, 2017Date of Patent: January 28, 2020Assignee: Hikal LimitedInventors: Rahul Bhalerao, R. Sridharan, Shivaji Sadashiv Kandre, Ganesh Suryakant Deore, Kishorkumar Shivajirao Kadam, Dharnidhar Mundhe
-
Publication number: 20190112273Abstract: The present invention relates to an improved process for the preparation of Butorphanol tartrate of formula (I),Type: ApplicationFiled: March 27, 2017Publication date: April 18, 2019Applicant: Hikal LimitedInventors: Rahul BHALERAO, R. SRIDHARAN, Shivaji Sadashiv KANDRE, Ganesh Suryakant DEORE, Kishorkumar Shivajirao KADAM, Dharnidhar MUNDHE
-
Patent number: 10023885Abstract: The present invention provides an improved process for the preparation of a compound of formula (I), which comprises the steps of: formula (I), (a) reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) optionally in presence of salts of weak acid and weak base or weak base in a suitable solvent to get 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV); (b) reacting 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV) with a suitable cyanide source in water or in an organic solvent or mixture thereof to get 2-isobutylsuccinonitrile of formula (V); (c) obtaining optionally 2-isobutylsuccinonitrile of formula (V) by reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) in presence of suitable cyanide source in water or in an organic solvent or mixture thereof in single step; (d) converting 2-isobutylsuccinonitrile of formula (V) to racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) with a genetically modified nitrilasType: GrantFiled: November 4, 2013Date of Patent: July 17, 2018Assignee: Hikal LimitedInventors: Swapnil Surendra Mohile, Swapnil Gulabrao Yerande, Sarika Madhukarrao Lunge, Rameshkumar Maghabhai Patel, Shivaji Balbhim Gugale, Rajesh Mataprasad Thakur, Ramesh Ananda Mokal, Ashok Kumar Gangopadhyay, Peter David Nightingale
-
Patent number: 8350045Abstract: A process for preparation of E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula-I, and acid addition salts thereof, said process comprising; dehydrating 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinopropan-1-ol of Formula III followed by adding a base solution to obtain a mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene, and washing said mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene with water to dissolve Z isomer and to obtain E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula I, which is substantially free from Z isomer.Type: GrantFiled: December 16, 2008Date of Patent: January 8, 2013Assignee: Hikal LimitedInventors: Rajender Pershad Gupta, Veerabhadra Swamy Hiremath, Raghavendra Arekal Vasanna, Vasantha Gowda Nekkilar
-
Publication number: 20110046384Abstract: A process for preparation of E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula-I, and acid addition salts thereof, said process comprising; dehydrating 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinopropan-1-ol of Formula III followed by adding a base solution to obtain a mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene, and washing said mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene with water to dissolve Z isomer and to obtain E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula I, which is substantially free from Z isomer.Type: ApplicationFiled: December 16, 2008Publication date: February 24, 2011Applicant: HIKAL LIMITEDInventors: Rajender Pershad Gupta, Veerabhadra Swamy Hiremath, Raghavendra Arekal Vasanna, Vasantha Gowda Nekkilar
-
Publication number: 20100311983Abstract: The present invention relates to a process for the preparation of substantially pure 2-cyanoimino-1,3-thiazolidine of Formula (I) by cyclization of dimethyl N-cyanoiminodithiocarbonate with 2-aminoethanethiol or the salt thereof in the presence of an alkali metal alkoxide. Further the present invention provides a process for the preparation of substantially pure 2-cyanoimino-1,3-thiazolidine of Formula (I) by cyclization of dimethyl N-cyanoiminodithiocarbonate with 2-aminoethanethiol or the salt thereof in the presence of aqueous ammonia.Type: ApplicationFiled: February 2, 2009Publication date: December 9, 2010Applicant: HIKAL LIMITEDInventors: Nagarajan Kuppuswamy, Rajender Pershad Gupta, Bhupathiraju Naga Satyanarayanaraju, Somu Madhava Reddy, Seranthimata Samshuddin, K. P. Jadhav, Sham Dhamnaskar
-
Patent number: 7635717Abstract: This invention relates to an improved process for the preparation of amino methyl cyclo alkane acetic acids. This invention particularly relates to an improved process for the preparation of gabapentin (which is chemically known as 1-aminomethyl-1-cyclohexaneacetic acid), which is a very well known agent useful for the treatment of epilepsy and other cerebral disorders. In the chemical series of 1-amino methyl cyclo alkane-1-acetic acids, Gabapentin, which is 1-amino methyl cyclo hexane-1-acetic acid has been developed as a drug having anti convulsive properties.Type: GrantFiled: November 20, 2002Date of Patent: December 22, 2009Assignee: Hikal LimitedInventors: Nagarajan Kuppuswamy, Sivaramakrishnan Hariharan, Arulselvan Mariadas
-
Patent number: 7632953Abstract: The present invention provides an improved process for the preparation of gabalactam of formula 1 that includes preparing an aqueous solution of an alkali or alkaline earth metal hydroxide, adding bromine to the resulting solution to give an appropriate alkali or alkaline earth metal hypobromite; adding an amide of the formula 4 aging the resultant mixture; heating the mixture to a temperature in a range of 80 to 100 degrees C.; extracting with nonpolar solvent and distilling under reduced pressure to obtain gabalactam.Type: GrantFiled: November 20, 2002Date of Patent: December 15, 2009Assignee: Hikal LimitedInventors: Nagarajan Kuppuswamy, Sivaramakrishnan Hariharan, Arulselvan Mariadas