Patents Assigned to HISTOCELL, S.L.
  • Publication number: 20220313769
    Abstract: The present invention is comprised in the cosmetic and/or therapeutic industry and specifically relates to a new composition for topical use with antioxidant and hydrating activity which promotes wound healing and is useful in therapeutic and/or cosmetic treatment, as well as in the prevention of skin lesions. The novel composition object of the present invention incorporates certain agents and ingredients, among which are carotenoids and the galactomannans, which surprisingly improve the healing and curing activity in a broad spectrum of wounds occurring with the presence of reactive oxygen species.
    Type: Application
    Filed: July 24, 2019
    Publication date: October 6, 2022
    Applicant: HISTOCELL, S.L.
    Inventors: Jone HERRERO DE MIGUEL, Maria Begona CASTRO FEO, Felix Daniel BASTIDA CORCUERA
  • Patent number: 11241516
    Abstract: The present invention refers to a process for preparing a biomaterial scaffold said method comprising, (a) providing a hydrogel comprising a fibrin network and a polysaccharide network; (b) subjecting the hydrogel of step a) to a freeze-thawing process to physically crosslink the hydrogel; and (c) subjecting the physically cross-linked hydrogel obtained after conducting the step b), to a lyophilization. The invention also relates to the biomaterial scaffold obtainable by the process as defined above, as well said biomaterial scaffold for its use to partially or completely increase, restore or replace the functional activity of a diseased or damaged oral mucosa.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: February 8, 2022
    Assignee: HISTOCELL, S.L.
    Inventors: María Begoña Castro Feo, Amparo Baiget Orts
  • Patent number: 10231992
    Abstract: The present invention relates to an antioxidant composition comprising a combination of galatomannan and N-acetyl cysteine for its use in the treatment of a skin disease or condition resulting from reactive oxygen species production in the skin or involving reactive oxygen species production in the skin, to a hydrogel containing said combination as well as to dressing wounds comprising said hydrogel and its use in the healing of ulcers, wounds, burns and scalds.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: March 19, 2019
    Assignee: HISTOCELL, S.L.
    Inventors: María Begoña Castro Feo, Iker Azcoitia Ramsden, Teodoro Palomares Casado, Jone Herrero De Miguel, Ana Isabel Alonso Varona, Maite Del Olmo Basterrechea
  • Patent number: 10226480
    Abstract: The present invention relates to a biomaterial, specifically a hydrogel, based on the extracellular matrix of the umbilical cord for its application in regenerative medicine. The invention particularly relates to a biomaterial made up of glycosaminoglycans present exclusively in the Wharton's jelly of the umbilical cord (which can optionally be combined with cells as a combination therapy), and also to the methods for the production and use thereof.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: March 12, 2019
    Assignee: HISTOCELL, S.L.
    Inventors: Julio Font Perez, Maria Begoña Castro Feo, Maite Del Olmo Basterrechea
  • Patent number: 9492475
    Abstract: The present invention relates to an antioxidant composition comprising a combination of galatomannan and N-acetyl cysteine for its use in the treatment of a skin disease or condition resulting from reactive oxygen species production in the skin or involving reactive oxygen species production in the skin, to a hydrogel containing said combination as well as to dressing wounds comprising said hydrogel and its use in the healing of ulcers, wounds, burns and scalds.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: November 15, 2016
    Assignee: HISTOCELL, S.L.
    Inventors: Maria Begoña Castro Feo, Iker Azcoitia Ramsden, Teodoro Palomares Casado, Jone Herrero De Miguel, Ana Isabel Alonso Varona, Maite Del Olmo Basterrechea
  • Patent number: 9320828
    Abstract: The present invention is comprised within tissue engineering and, specifically, within bone regeneration. The invention relates to a porous three-dimensional matrix of monetite which is biocompatible, has structured porosity and is predefined and reabsorbable, as well as to the method of synthesis capable of producing said material and the applications thereof. These matrices are a perfect base for cell colonization and proliferation, allowing the application thereof in tissue engineering and bone regeneration as a result of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularization, etc.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: April 26, 2016
    Assignee: HISTOCELL, S.L.
    Inventors: Julio Font Pérez, Maria Begoña Castro Feo, Maite Del Olmo Basterrechea, Maria Dolores García Vázquez, Jorge Rubio Retama, Enrique López Cabarcos, Carmen Rueda Rodríguez, Faleh Tamimi Mariño, Mohammad Hamdan Ali Alkhraisat
  • Patent number: 9080153
    Abstract: The present invention relates to a method of treatment of mesenchymal stem cells, preferably from adipose origin, comprising mainly two stages, firstly the collection and isolation of mesenchymal stem cells, and secondly, a period of growth and specific treatment of cells in a conditioning or treatment medium with an oxidizing agent. The invention also comprises the cells obtained directly through the method and its use in treating diseases caused by or associated with oxidative stress.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: July 14, 2015
    Assignee: HISTOCELL S.L.
    Inventors: Maria Begona Castro, Javier Diez Garcia
  • Publication number: 20140154221
    Abstract: The present invention relates to a method of treatment of mesenchymal stem cells, preferably from adipose origin, comprising mainly two stages, firstly the collection and isolation of mesenchymal stem cells, and secondly, a period of growth and specific treatment of cells in a conditioning or treatment medium with an oxidizing agent. The invention also comprises the cells obtained directly through the method and its use in treating diseases caused by or associated with oxidative stress.
    Type: Application
    Filed: July 6, 2011
    Publication date: June 5, 2014
    Applicant: HISTOCELL S.L.
    Inventors: Maria Begona Castro, Javier Diez Garcia
  • Patent number: 8709803
    Abstract: The present invention relates to a system for cell transport Said system allows the transport of cells, assuring their integrity and viability during the entire transport process. It consists of a system suitable for a wide variety of formats which allows a broad range of technical applications of the system The system of the invention allows providing ready-to-use cells, without the cells having to be manipulated before they are used by technical experts in cell biology The invention particularly relates to an agarose plus agarase mixture covering or enveloping, depending on the format of the selected transport system, the cell culture, protecting it during the transport process, as well as to the methodology of cell recovery of the cells transported in the system.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: April 29, 2014
    Assignee: Histocell, S.L.
    Inventors: Miren Itxaso Gartzia Aranaga, Maite Del Olmo Basterrechea, Maria Begoña Castro Feo, Marta Acilu Perez
  • Patent number: 8685732
    Abstract: The present invention relates to a biomaterial, specifically a hydrogel, formed from the extracellular matrix of the umbilical cord for its application in regenerative medicine. The invention particularly relates to a biomaterial made up of glycosaminoglycans isolated exclusively from the Wharton's jelly of the umbilical cord which can optionally contain cells, and also to the methods for the production and use thereof.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: April 1, 2014
    Assignee: Histocell, S.L.
    Inventors: Julio Font Perez, Maite Del Olmo Basterrechea, Maria Begona Castro Feo, Arantza Infante Martinez, Ana Isabel Alonso Varona, Teodoro Palomares Casado
  • Publication number: 20130095049
    Abstract: The present invention relates to an antioxidant composition comprising a combination of galatomannan and N-acetyl cysteine for its use in the treatment of a skin disease or condition resulting from reactive oxygen species production in the skin or involving reactive oxygen species production in the skin, to a hydrogel containing said combination as well as to dressing wounds comprising said hydrogel and its use in the healing of ulcers, wounds, burns and scalds.
    Type: Application
    Filed: June 14, 2011
    Publication date: April 18, 2013
    Applicant: HISTOCELL, S.L.
    Inventors: Maria Begoña Castro Feo, Iker Azcoitia Ramsden, Teodoro Palomares Casado, Jone Herrero De Miguel, Ana Isabel Alonso Varona, Maite Del Olmo Basterrechea
  • Publication number: 20130095143
    Abstract: The present invention relates to a biomaterial, specifically a hydrogel, based on the extracellular matrix of the umbilical cord for its application in regenerative medicine. The invention particularly relates to a biomaterial made up of glycosaminoglycans present exclusively in the Wharton's jelly of the umbilical cord (which can optionally be combined with cells as a combination therapy), and also to the methods for the production and use thereof.
    Type: Application
    Filed: March 30, 2010
    Publication date: April 18, 2013
    Applicant: HISTOCELL, S.L.
    Inventors: Julio Font Perez, Maria Begoña Castro Feo, Maite Del Olmo Basterrechea
  • Publication number: 20120135445
    Abstract: The present invention relates to a system for cell transport Said system allows the transport of cells, assuring their integrity and viability during the entire transport process. It consists of a system suitable for a wide variety of formats which allows a broad range of technical applications of the system The system of the invention allows providing ready-to-use cells, without the cells having to be manipulated before they are used by technical experts in cell biology The invention particularly relates to an agarose plus agarase mixture covering or enveloping, depending on the format of the selected transport system, the cell culture, protecting it during the transport process, as well as to the methodology of cell recovery of the cells transported in the system.
    Type: Application
    Filed: December 18, 2009
    Publication date: May 31, 2012
    Applicant: HISTOCELL, S.L.
    Inventors: Miren Itxaso Gartzia Aranaga, Maite Del Olmo Basterrechea, Maria Begoña Castro Feo, Marta Acilu Perez
  • Publication number: 20110256186
    Abstract: The present invention relates to a biomaterial, specifically a hydrogel, formed from the extracellular matrix of the umbilical cord for its application in regenerative medicine. The invention particularly relates to a biomaterial made up of glycosaminoglycans isolated exclusively from the Wharton's jelly of the umbilical cord which can optionally contain cells, and also to the methods for the production and use thereof.
    Type: Application
    Filed: October 10, 2008
    Publication date: October 20, 2011
    Applicant: HISTOCELL, S.L.
    Inventors: Julio Font Perez, Maite Del Olmo Basterrechea, Maria Begona Castro Feo, Arantza Infante Martinez, Ana Isabel Alonso Varona, Teodoro Palomares Casado
  • Publication number: 20110158963
    Abstract: The present invention is comprised within tissue engineering and, specifically, within bone regeneration. The invention relates to a porous three-dimensional matrix of monetite which is biocompatible, has structured porosity and is predefined and reabsorbable, as well as to the method of synthesis capable of producing said material and the applications thereof. These matrices are a perfect base for cell colonization and proliferation, allowing the application thereof in tissue engineering and bone regeneration as a result of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularization, etc.
    Type: Application
    Filed: July 8, 2009
    Publication date: June 30, 2011
    Applicant: HISTOCELL, S.L.
    Inventors: Julio Font Pérez, Maria Begoña Castrofeo, Maite Del Olmo Basterrechea, Maria Dolores García Vázquez, Jorge Rubio Retama, Enrique López Cabarcos, Carmen Rueda Rodríguez, Faleh Tamini Mariño, Mohammad Hamdan Ali Alkhraisat