Patents Assigned to Histogen, Inc.
  • Caspase inhibitors and methods of use thereof
    Patent number: 11597703
    Abstract: Provided herein are compounds of formula I, compositions comprising the compounds and method of treating various diseases with the compounds and compositions.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: March 7, 2023
    Assignee: Histogen, Inc.
    Inventors: Alfred P. Spada, Robert J. Temansky, Michael Mueller
  • (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
    Patent number: 11447497
    Abstract: The present invention relates to (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating e.g. cardiovascular, kidney, liver, lung, skin, joints, CNS, inflammatory and autoimmune diseases.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: September 20, 2022
    Assignee: Histogen, Inc.
    Inventors: Alfred P. Spada, Robert J. Ternansky
  • Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions
    Patent number: 11274276
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: March 15, 2022
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Francis C. Zeigler, Mark Baumgartner, Kyle Nickey
  • Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions
    Patent number: 10538736
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: January 21, 2020
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Francis C. Zeigler, Mark Baumgartner, Kyle Nickey
  • Extracellular matrix compositions for the treatment of cancer
    Patent number: 10143708
    Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: December 4, 2018
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Emmett Pinney
  • Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions for methods of treating tissue injury
    Patent number: 9512403
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: December 6, 2016
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • Extracellular matrix compositions for the treatment of cancer
    Patent number: 9506038
    Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: November 29, 2016
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Emmett Pinney
  • Extracellular matrix compositions for the treatment of cancer
    Patent number: 9034312
    Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: May 19, 2015
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Emmett Pinney
  • Extracellular matrix compositions for the treatment of cancer
    Patent number: 8852637
    Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: October 7, 2014
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Emmett Pinney
  • Conditioned Medium and Extracellular Matrix Compositions from Cells Cultured under Hypoxic Conditions
    Publication number: 20130344161
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Application
    Filed: August 27, 2013
    Publication date: December 26, 2013
    Applicant: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
    Patent number: 8535913
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible three-dimensional surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: September 17, 2013
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
    Patent number: 8530415
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible three-dimensional surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: September 10, 2013
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
    Patent number: 8524494
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: September 3, 2013
    Assignee: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • EXTRACELLULAR MATRIX COMPOSITIONS FOR THE TREATMENT OF CANCER
    Publication number: 20110097403
    Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.
    Type: Application
    Filed: June 23, 2010
    Publication date: April 28, 2011
    Applicant: Histogen, Inc.
    Inventors: Gail K. Naughton, Emmett Pinney
  • EXTRACELLULAR MATRIX COMPOSITIONS
    Publication number: 20100210530
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible three-dimensional surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Application
    Filed: December 7, 2009
    Publication date: August 19, 2010
    Applicant: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • CONDITIONED MEDIUM AND EXTRACELLULAR MATRIX COMPOSITIONS FROM CELLS CULTURED UNDER HYPOXIC CONDITIONS
    Publication number: 20100196963
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Application
    Filed: August 25, 2009
    Publication date: August 5, 2010
    Applicant: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • EXTRACELLULAR MATRIX COMPOSITIONS
    Publication number: 20100166824
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible three-dimensional surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Application
    Filed: July 10, 2009
    Publication date: July 1, 2010
    Applicant: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • EXTRACELLULAR MATRIX COMPOSITIONS
    Publication number: 20100158975
    Abstract: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible three-dimensional surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.
    Type: Application
    Filed: July 24, 2009
    Publication date: June 24, 2010
    Applicant: Histogen, Inc.
    Inventors: Gail K. Naughton, Frank Ziegler, Mark Baumgartner, Kyle Nickey
  • EXTRACELLULAR MATRIX COMPOSITIONS FOR THE TREATMENT OF CANCER
    Publication number: 20100124573
    Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.
    Type: Application
    Filed: January 30, 2009
    Publication date: May 20, 2010
    Applicant: Histogen, Inc.
    Inventors: Gail K. Naughton, Emmett Pinney
  • COMPOSITION AND METHODS FOR PROMOTING HAIR GROWTH
    Publication number: 20100034787
    Abstract: The present disclosure provides compositions and methods for promoting the growth of hair for cosmetic purposes as well as for treating disorders of hair growth. The compositions are conditioned media obtained from a three dimensional tissue that produces a combination of cellular factors effective to induce, promote, or enhance hair growth.
    Type: Application
    Filed: October 15, 2009
    Publication date: February 11, 2010
    Applicant: Histogen, Inc.
    Inventor: Gail K. Naughton