Patents Assigned to HMGene Inc.
  • Promoting Apoptosis Of Differentiated Adipocytes And Increasing Endogenous Expression Of sFRP-5 Peptide By Adipocytes By Administration Of sFRP-5 Peptide
    Publication number: 20160024162
    Abstract: Disclosed is a method of reducing the amount of adipose tissue in a subject comprising administering to the subject an amount of an sFRP-5 peptide effective to reduce the amount of adipose tissue, or an amount of a molecule effective to stimulate expression of the sFRP-5 peptide in the subject. Also disclosed is a screen for molecules that can reduce the amount of adipose tissue in a subject.
    Type: Application
    Filed: August 3, 2015
    Publication date: January 28, 2016
    Applicant: HMGENE INC.
    Inventors: Kiran K. Chada, Roland Chouinard, Hena Ashar, Abu Sayed
  • Method of promoting apoptosis of differentiated adipocytes and increasing endogenous expression of SFRP-5 peptide by administration of SFRP-5 peptide
    Patent number: 8211853
    Abstract: Disclosed is a method of reducing the amount of adipose tissue in a subject comprising administering to the subject an amount of an sFRP-5 peptide effective to reduce the amount of adipose tissue, or an amount of a molecule effective to stimulate expression of the sFRP-5 peptide in the subject. Also disclosed is a screen for molecules that can reduce the amount of adipose tissue in a subject.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: July 3, 2012
    Assignee: HMGene Inc.
    Inventors: Kiran K. Chada, Roland Chouinard, Hena Ashar, Md. Abu Sayed
  • Methods of identifying adipocyte specific genes, the genes identified, and their uses
    Patent number: 7879544
    Abstract: Disclosed is a method of identifying genes that are over-expressed in adipose tissue as compared to pre-adipocyte tissue or other tissues comprising performing differential gene expression analysis between the white adipose tissue (WAT) or stromal vascular tissue (SVT) from any two different mice selected from the group consisting of wild-type, HMGI-C ?/?, ob/ob, and HMGI-C ?/? ob/ob genotype mice. Based on this method a number of nucleotide sequences are identified whose expression is adipocyte specific. The identified nucleotide sequences and their corresponding polypeptides are then used to prevent adipogenesis, to treat diabetes, and to screen for small-molecules that can modulate or prevent adipogenesis and to treat diabetes.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: February 1, 2011
    Assignee: HMGene Inc.
    Inventors: Kiran K. Chada, Roland Chouinard, Hena Ashar, Abu Sayed
  • Method of reducing adipocyte growth in a subject in need thereof by administration of natriuretic peptide receptor C inhibitors
    Patent number: 7419951
    Abstract: Disclosed is a method of using synthetic analogs of natriuretic peptides and more particularly to synthetic linear peptide analogs as pro-lipolytic, as anti-obesity agents, and as intermediates for or modulators of such useful compounds. Inhibitors to nprC are disclosed to treat or prevent adipose accumulation in mammals.
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: September 2, 2008
    Assignee: HMGene Inc.
    Inventors: Kiran K. Chada, Roland Chouinard, Hena Ashar, Abu Sayed