Patents Assigned to Hoechst Aktiengesllschaft
  • Combination preparation for use in immunological diseases
    Patent number: 5990103
    Abstract: A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca.sup.2+ content, is suitable for the treatment of immunological diseases.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: November 23, 1999
    Assignee: Hoechst Aktiengesllschaft
    Inventors: Martin Schonharting, Stefan Mullner, Peter Zabel
  • Method for preparing 3-alkyl-2,6-dichloroacylanilides by electrolytic debromination of 3-alkyl-4-bromo-2,6-dichloroacylanilides
    Patent number: 5558754
    Abstract: A method for preparing 3-alkyl-2,6-dichloroacylanilides by electrolytic debromination of 3-alkyl-4-bromo-2,6-dichloroacylanilides.A method for preparing a 3-alkyl-2,6-dichloroacylanilide of the formula I ##STR1## in which R.sup.1, R.sup.2 are, independently of one another, (C.sub.1 -C.sub.4)-alkyl, by bromoalkylacylanilides of the formula II ##STR2## in which R.sup.1, R.sup.2 have the above-specified meaning, being electrolytically debrominated.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: September 24, 1996
    Assignee: Hoechst Aktiengesllschaft
    Inventor: Thomas Karcher
  • 2-substituted 4-(3-alkyl-5-tert.-butyl-4-hydroxyphenyl) thiazoles, processes for their preparation, pharmaceuticals containing them and their use
    Patent number: 5137897
    Abstract: Novel substituted thiazoles of the formula I ##STR1## in which R.sup.1 is a saturated or unsaturated, straight-chain or branched C.sub.1 -C.sub.5 -alkyl group,R.sup.2 is a hydrogen atom or an alkyl radical having 1 to 3 carbon atoms,A is an intermediate chain of the formula--(CH.sub.2).sub.n --Y--CR.sup.3 R.sup.4 --; --CH.dbd.CR.sup.3 --(CH.sub.2).sub.m -- or --CH.dbd.N--O--(CH.sub.2).sub.n --whereY is a single bond, an oxygen or sulfur atom or a carbonyl group,R.sup.3 and R.sup.4 are identical or different and are a hydrogen atom or an alkyl radical having up to two carbon atoms, m is a number from 0 to 3 and n is a number from 1 to 4, andZ is a tetrazole or CN group, or a radical of the formula ##STR2## X is a hydroxyl group or a radical of the formula R.sup.5 O-- or R.sup.6 R.sup.7 N--, where R.sup.5 is a straight-chain or branched C.sub.1 -C.sub.4 -alkyl radical which is optionally substituted by hydroxyl, C.sub.1 -C.sub.3 -alkoxy or C.sub.1 -C.sub.3 -alkylamino,R.sup.6 and R.sup.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: August 11, 1992
    Assignee: Hoechst Aktiengesllschaft
    Inventors: Werner Thorwart, Rudolf Schleyerbach, Robert Bartlett, Klaus U. Weithmann