Patents Assigned to Hoeschst Marion Roussel
  • Method of treating menopause or perimenopause
    Patent number: 6011026
    Abstract: A method of treating menopause or perimenopause without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR1## wherein the substituents are defined as in the specification sufficient to treat menopause or perimenopause symptoms without estrogenic activity at the uterine level.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: January 4, 2000
    Assignee: Hoeschst Marion Roussel
    Inventors: Yamina Bouali, Daniel Philibert, Francois Nique, Jean-Georges Teutsch, Patrick Van De Velde
  • Process for the preparation of ribonucleotide reductase inhibitors
    Patent number: 5508393
    Abstract: The present invention is directed toward a novel process of preparing 2'-exocyclic vinylfluoride derivatives of cytidine analogues for use as ribonucleotide reductase inhibitors. The novel process of the present invention utilizes a cytidine derivative as the required starting material and provides the ribonucleotide reductase inhibitor in a more efficient five step reaction sequence. The present invention further provides the ribonucleotide reductase inhibitor in a four step reaction sequence and results in an overall yield of greater than 35%.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: April 16, 1996
    Assignee: Hoeschst Marion Roussel, Inc.
    Inventors: James R. McCarthy, Donald P. Matthews, Jeffrey S. Sabol, James R. McConnell, Richard E. Donaldson, Robert Duquid