Abstract: A glider tool can be provided for installing a back panel of an enclosure. The glider tool can include a body having a first surface, a second surface opposite the first surface, a first end, and a second end opposite the first end, the body defining a length that extends from the first end to the second end. The first end of the body can be configured to engage a front frame member of the enclosure, and the second end of the body can be configured to contact the enclosure, when the glider tool is in an installed configuration.

Abstract: The present invention generally relates to the provision of means and methods for preparing protein compositions. The invention provides a method comprising the steps of (i) contacting a starting composition comprising a protein with a hydrolase inhibitor, wherein the hydrolase inhibitor is immobilized on a solid carrier; (ii) recovering a composition comprising the protein. Furthermore, the invention relates to a method for preparing a protein formulation comprising the steps of (i) contacting a starting composition comprising a protein with a hydrolase inhibitor, wherein the hydrolase inhibitor is immobilized on a solid carrier; (ii) recovering a composition comprising the protein, wherein the method for preparing the protein formulation further comprises adding a surfactant, preferably a fatty acid ester, to the composition comprising the protein.

Abstract: The present invention relates to anti-VEGF antibodies and methods of their production and their use.

Abstract: An enclosure can have an enclosure body, the enclosure body can include an enclosure frame, and a first enclosure flange. The enclosure can have a center post having a first end and an opposite second end, the first end can include a first center post flange having a hole extending therethrough. The enclosure can include a gasket having a gasket hole therethrough, and a threaded fastener to threadingly engage the hole. The threaded fastener can be configured to rotate in a first direction while threadingly engaged with the hole, and the threaded fastener can contact the first enclosure flange to increase a distance between the first enclosure flange and the first center post flange in order to receive the gasket.

Abstract: A hole seal is provided that can include a plate having a surface configured to face away from an enclosure wall of an enclosure, and a peripheral extension that is angled away from the surface. The hole seal can include a stud coupled to and extending away from the plate, a gasket, a retaining member configured to engage an enclosure wall of an enclosure opposite the gasket, and a fastener. The fastener is configured to threadingly engage the stud and be advanced along the stud to urge the retaining member against the enclosure wall, thereby urging a peripheral extension of the plate into the gasket, via compression of the gasket against an exterior surface of the enclosure wall.

Abstract: A method of manufacturing a wafer holder, the wafer holder having a frame having at least one cavity capable of receiving and supporting a wafer grown from an ingot to be polished in a polishing machine, the at least one cavity having a cross sectional footprint at least equal to a cross sectional footprint of the wafer, the wafer having a thickness to cross sectional area ratio of 0.001 per unit length or less, a polymer film pad being permanently affixed in the at least one cavity, including cutting a frame from a layer of a thermoset or thermoplastic material having a thickness tolerance and measuring a thickness of the frame at at least one location thereon. The method further includes forming a cavity in the frame having a predetermined depth, and permanently affixing a polymer film pad in the cavity.

Abstract: Various aspects of the invention relate to recombinant polypeptides that specifically bind human von Willebrand Factor. Such recombinant polypeptides typically include a modified extracellular domain of platelet glycoprotein Ib? that typically comprises at least one mutation selected from G233T, D235V, and K237V, and such recombinant polypeptides optionally include an oligomerization domain.

Abstract: A thermal management system for an enclosure containing electrical components includes a cooling unit for controlling temperature inside the enclosure and a controller for the cooling unit, the controller being configured so that it can receive a three-phase power input signal and distribute power and control connected components using the three-phase signal. The controller can protect the compressor in critical scenarios such as thermal overload and overcurrent. The controller can output various faults such as missing phase alarm, imbalance phase alarm, overcurrent alarm, thermal overload alarm, door open alarm, and temperature and pressure alarms. An auto phase sequence correction controls the phase relay, accepting 3 phase 480 VAC power input from facility power terminal, supplying 3 phase power to the compressor and motor impellers, 12V DC power to a display unit, and 24V DC power to a remote access control module.

Abstract: Embodiments disclosed herein generally relate to multi-arm machine learning models for lesion detection. Particularly, aspects of the present disclosure are directed to accessing a three-dimensional magnetic resonance imaging (MRI) images. Each of the three-dimensional MRI images depict a same volume of a brain of a subject. The volume of the brain includes at least part of one or more lesions. Each three-dimensional MRI image of the three-dimensional MRI images is processed using one or more corresponding encoder arms of a machine-learning model to generate an encoding of the three-dimensional MRI image. The encodings of the three-dimensional MRI images are concatenated to generate a concatenated representation. The concatenated representation is processed using a decoder arm of the machine-learning model to generate a prediction that identifies one or more portions of the volume of the brain predicted to depict at least part of a lesion.

Abstract: The present invention relates to compounds of formula (I), (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: Methods are provided for the adjuvant treatment of operable HER2-positive primary breast cancer in human patients by administration of pertuzumab in addition to chemotherapy and trastuzumab. The methods reduce the risk of recurrence of invasive breast cancer or death for a patient diagnosed with HER2-positive early breast cancer (eBC) compared to administration of trastuzumab and chemotherapy, without pertuzumab.

Abstract: The present invention relates to nucleic acid molecules that are complementary to both PAP associated domain containing 5 (PAPD5) and PAP associated domain containing 7 (PAPD7), leading to inhibition of the expression of both PAPD5 and PAPD7 when using a single nucleic acid molecule. The invention also provides for PAPD5 and PAPD7 specific nucleic acid molecules for use in treating and/or preventing a HBV infection, in particular a chronic HBV infection. Also comprised in the present invention is a pharmaceutical composition for use in the treatment and/or prevention of a HBV infection.

Abstract: The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.

Abstract: The method includes generating, for each of a plurality of original images, a first artificially degraded image by applying a first image-artifact-generation logic on each of the original images; and generating the program logic by training an untrained version of a first machine-learning logic that encodes a first artifacts-removal logic on the original images and their respectively generated first degraded images; and returning the trained first machine-learning logic as the program logic or as a component thereof. The first image-artifact-generation logic is A) an image-acquisition-system-specific image-artifact-generation logic or B) a tissue-staining-artifact-generation logic.

Abstract: The present invention relates to nucleic acid molecules that are complementary to both PAP associated domain containing 5 (PAPD5) and PAP associated domain containing 7 (PAPD7), leading to inhibition of the expression of both PAPD5 and PAPD7 when using a single nucleic acid molecule. The invention also provides for PAPD5 and PAPD7 specific nucleic acid molecules for use in treating and/or preventing a HBV infection, in particular a chronic HBV infection. Also comprised in the present invention is a pharmaceutical composition for use in the treatment and/or prevention of a HBV infection.

Abstract: The invention relates to a method of identifying a biomarker in a tissue sample. The method comprises receiving an acquired image depicting a tissue sample, the pixel intensity values of the acquired image correlating with an autofluorescence signal or of an X-ray induced signal or a signal of a non-biomarker specific stain or a signal of a first biomarker specific stain adapted to selectively stain a first biomarker. The acquired image is input into a trained machine learning logic—MLL which automatically transforms the acquired image into an output image highlighting tissue regions predicted to comprise a second biomarker.