Abstract: Described is a compressible tube comprising a tube body made of a specific laminate and shoulder and applicator, said applicator being suitable for applying a tube content in dosed droplets and comprises a sterile venting valve. The tube body has a restoring force (R) sufficient to essentially restore the original volume of the tube body after each of a predetermined number of applications. Such tube is especially suitable for the application of ophthalmic sterile drops.

Abstract: A collapsible container is provided with a one-way valve. The valve comprises a cupola shaped slitted membrane forming a closure head to allow dispensing a liquid contained in the container by opening the membrane under liquid pressure. When pressure is reduced the membrane will close and prevent the entrance of air into the container. To avoid a deformation of the membrane in counter dispensing direction a supporting column is arranged within the valve ending in a distance from the lower side of the membrane. This column will prevent an opening of the membrane closure head towards the container storage room when air pressure in direction into the container is too high to be borne by the membrane closure head alone.

Abstract: The disclosure relates to tube with a tube head (4) and a container (5) made of resilient material, wherein the tube head (4) is connected to the container (5), wherein the tube head (4) comprises a female Luer lock fitting (7) with a flow passage (17), the female Luer lock fitting (7) being designed for sealingly receiving a male Luer lock fitting (9) of a syringe (2), wherein a tamper-evident closure (11, 12, 13, 14) is arranged at the inner surface of the female Luer lock fitting (7) such that it closes the flow passage (17) in a closed state of the tube (1).