Abstract: The invention provides novel compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R2?, R3, R4 and R5 are as described herein. The compound of formula (I) can be used as a medicament.
Type:
Application
Filed:
November 29, 2021
Publication date:
January 4, 2024
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Cosimo DOLENTE, Annick GOERGLER, David Stephen HEWINGS, Georg JAESCHKE, Ulrike OBST SANDER, Antonio RICCI
Abstract: Compounds having the general formula (I) wherein R1, R2, R3, R4, R5 and X are as described herein, compositions including the compounds and methods of using the compounds.
Type:
Application
Filed:
July 20, 2023
Publication date:
January 4, 2024
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Giuseppe CECERE, Luca GOBBI, Maria-Clemencia HERNANDEZ, Frédéric KNOFLACH, Andreas KOBLET, Eoin Cornelius O'CONNOR, Andres Miguel OLIVARES MORALES, Michael REUTLINGER, Valerie RUNTZ-SCHMITT, Jaclyn Ivy WAMSTEEKER CUSULIN, Nicolas ZORN
Abstract: The invention relates in particular to a process for the preparation of a compound of formula (I) wherein R1 and R2 are as defined in the description and in the claims.
Type:
Application
Filed:
May 22, 2023
Publication date:
January 4, 2024
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Dainis KALDRE, Christian Oliver KAPPE, Christian Steffen MOESSNER, Peter SAGMEISTER, Joerg Mathias SEDELMEIER, Jason Douglas WILLIAMS
Abstract: Disclosed are techniques for using artificial intelligence (AI) to facilitate the selection of lines of therapy for subjects diagnosed with cancer. Methods and systems disclosed herein relate to techniques for using AI to predict therapeutic outcomes and cancer evolution in subjects based on mutation profiles of subjects across cancer types, to predict treatment survival prospects for subjects using enriched subject-specific data sets, and to automatically validate whether the reasons (e.g., represented by features in a subject record) that contributed to the selection of a particular line of therapy comply with oncological treatment guidelines.
Type:
Application
Filed:
October 6, 2021
Publication date:
January 4, 2024
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Silvia Elena MOLERO LEON, Turap Tasoglu
Abstract: Methods and systems for determining a location of an individual in a home, business, structure, or other finite amount of space using one or more beacons.
Type:
Application
Filed:
June 29, 2023
Publication date:
January 4, 2024
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Christopher Hughes CHATHAM, Joerg Felix HIPP, Lito KRIARA, Michael LINDEMANN, Florian LIPSMEIER, David NOBBS, David Alexander SLATER
Abstract: A force testing machine (FTM) validation apparatus is disclosed for validating a test process involving a force testing machine to measure forces involved in operation of a syringe arrangement. Particularly a syringe arrangement that includes a staked-in needle prefilled syringe and a needle safety device cooperating with the staked-in needle prefilled syringe. The FTM validation apparatus includes a syringe arrangement surrogate, and a holder arranged to support the syringe arrangement surrogate in a predefined position and orientation in the force testing machine. The syringe arrangement surrogate includes a break loose part arranged to mimic a break loose force of the syringe arrangement and an injection force part arranged to mimic an injection force of the syringe arrangement. Methods are also disclosed for validating a test process that measures forces involved in operation of a syringe arrangement and for measuring forces involved in operation of the syringe arrangement.
Type:
Grant
Filed:
August 19, 2022
Date of Patent:
January 2, 2024
Assignee:
HOFFMANN-LA ROCHE INC.
Inventors:
Sascha Dreher, Martin Vogelmann, Thorben Hammerich, Eva Conraths, Paolo Moroni, Georg Cramm
Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
Type:
Grant
Filed:
July 14, 2022
Date of Patent:
January 2, 2024
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Mathis Braendlin, Sandra Marie Joseph Grall-Ulsemer, Xingchun Han, Christian Lerner, Mingming Li, Yongqiang Liu, Sébastien Schmitt, Jianhua Wang, Yongguang Wang, Min Wang, Song Yang, Chengang Zhou
Abstract: The present invention generally relates to bispecific antibodies that bind to CD3 and Folate Receptor 1 (FolR1), e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
Type:
Application
Filed:
December 15, 2022
Publication date:
December 28, 2023
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Peter BRUENKER, Martina GEIGER, Christian KLEIN, Alexander KNAUPP
Abstract: The present invention relates to anti-CD3/anti-CD28 bispecific antigen binding molecules and masked protease activated forms thereof, methods for their production, pharmaceutical compositions containing these molecules, and their use as immunomodulators and/or costiumulators in the treatment of a disease, in particular cancer.
Type:
Application
Filed:
December 21, 2022
Publication date:
December 28, 2023
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Peter BRUENKER, Martina GEIGER, Thomas HOFER, Christian KLEIN, Pablo UMAÑA
Abstract: The present invention relates to tumor targeted bispecific agonistic antigen binding molecules characterized by monovalent binding to CD28, methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.
Type:
Application
Filed:
November 17, 2022
Publication date:
December 28, 2023
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Guy GEORGES, Thomas HOFER, Ralf HOSSE, Christian KLEIN, Ekkehard MOESSNER, Johannes SAM, Pablo UMAÑA, Jenny THOM, Stephan GASSER, Jean-Baptiste VALLIER, Tanja FAUTI
Abstract: The present invention relates to the prevention or mitigation of adverse effects related to T cell engaging agents, such as cytokine release syndrome. Specifically, the invention relates to the prevention or mitigation of such side effects using an inhibitor of NACHT, LRR and PYD domains-containing protein 3 (NLRP3).
Type:
Application
Filed:
May 26, 2023
Publication date:
December 28, 2023
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Gabrielle LECLERCQ-COHEN, Johannes SAM, Nathalie STEINHOFF, Pablo UMAÑA
Abstract: The present invention provides novel compounds having the general formula: wherein A1 to A4, X, Cy and R1 are as described herein, compositions including the compounds and methods of using the compounds.
Type:
Application
Filed:
May 18, 2023
Publication date:
December 28, 2023
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Xianfeng LIN, Hongying YUN, Bo ZHANG, Xiufang ZHENG
Abstract: The method includes generating, for each of a plurality of original images, a first artificially degraded image by applying a first image-artifact-generation logic on each of the original images; and generating the program logic by training an untrained version of a first machine-learning logic that encodes a first artifacts-removal logic on the original images and their respectively generated first degraded images; and returning the trained first machine-learning logic as the program logic or as a component thereof. The first image-artifact-generation logic is A) an image-acquisition-system-specific image-artifact-generation logic or B) a tissue-staining-artifact-generation logic.
Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.
Type:
Grant
Filed:
January 21, 2022
Date of Patent:
December 26, 2023
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Veronica Costa, Maj Hedtjärn, Marius Hoener, Ravi Jagasia, Mads Aaboe Jensen, Christoph Patsch, Lykke Pedersen, Søren Vestergaard Rasmussen
Abstract: The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Type:
Application
Filed:
January 5, 2023
Publication date:
December 14, 2023
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Monika Baehner, Ulrich Brinkmann, Guy Georges, Remko Albert Griep, Sabine lmhof-Jung, Anita Kavlie, Hubert Kettenberger, Christian Klein, Joerg Thomas Regula, Wolfgang Schaefer, Juergen Michael Schanzer, Werner Scheuer, Stefan Seeber, Markus Thomas
Abstract: Herein is reported a co-cultivation system for co-cultivating a pool of rabbit B-cells or single deposited rabbit B-cells wherein cells CD40L expressing CHO cells are used as feeder in the presence of TL-2 and TL-21.
Type:
Application
Filed:
August 11, 2022
Publication date:
December 14, 2023
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Josef Endl, Jens Fischer, Peter Kern, Sonja Offner, Josef Platzer, Stefan Seeber
Abstract: The invention provides novel compounds having the general formula (I) or (II) wherein R2, R3, R5, R99, W, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.
Type:
Grant
Filed:
December 11, 2020
Date of Patent:
December 12, 2023
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Giuseppe Cecere, Katrin Groebke Zbinden, Maria-Clemencia Hernandez, Henner Knust, Andreas Koblet, Andres Miguel Olivares Morales, Angélique Patiny-Adam, Emmanuel Pinard, Valerie Runtz-Schmitt, Sandra Steiner
Abstract: Herein is reported a method for determining free antigen of an antibody in an undiluted serum sample comprising the steps of a) applying the undiluted sample to a solid phase on which a capture antibody has been immobilized to form a capture antibody-antigen complex, wherein the capture antibody competes with the antibody for binding to a first epitope on the antigen, b) applying to the solid phase a tracer antibody to form a capture antibody-antigen-tracer antibody complex, wherein the tracer antibody specifically binds to a second epitope on the antigen, wherein the epitope of the tracer antibody is not overlapping with the epitope of the capture antibody on the antigen, and c) determining the free antigen of the antibody by determining the tracer antibody in the capture antibody-antigen-tracer antibody complex.
Type:
Application
Filed:
December 16, 2022
Publication date:
December 7, 2023
Applicant:
Hoffmann-La Roche Inc.
Inventors:
Gregor JORDAN, Martin SCHAEFER, Maria VIERT