Abstract: Compounds of the formula:
are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
Type:
Grant
Filed:
April 5, 2002
Date of Patent:
October 19, 2004
Assignee:
Hoffmann-La Rocher Inc.
Inventors:
Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull