Patents Assigned to Hoffmann-Le Roche Inc.
  • BACE1 inhibitors
    Patent number: 10723729
    Abstract: The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: July 28, 2020
    Assignee: Hoffmann-Le Roche Inc.
    Inventors: Bjoern Bartels, Cosimo Dolente, Wolfgang Guba, Wolfgang Haap, Ulrike Obst Sander, Jens-Uwe Peters, Thomas Woltering
  • Diphenyl-dihydro-imidazopyridinones
    Patent number: 7625895
    Abstract: and the pharmaceutically acceptable salts and esters thereof, X, R1, R2, Y1 and Y2 are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: December 1, 2009
    Assignee: Hoffmann-Le Roche Inc.
    Inventors: Romyr Dominique, Robert Alan Goodnow, Jr., Qi Qiao, Binh Thanh Vu