Abstract: The present invention provides a method for detecting synthetic indole and indazole cannabinoids in a sample known or suspected to contain a synthetic indole or indazole cannabinoid. A deuterated solvent is added to the solid sample, creating a suspension. The suspension is mixed to release the cannabinoid from the solid sample. The suspension is subject to a NMR spectroscopy process to produce a sample NMR spectrum. The synthetic cannabinoid is detected in the suspension by analysis of the sample NMR spectrum. When one-dimensional proton NMR is used, detection of a first peak between 8.00 and 8.50 ppm and a second peak between 4.00 and 4.40 ppm, indicates the presence of a synthetic indole or indazole cannabinoid. When two-dimensional Correlation Spectroscopy (COSY) NMR is used, detection of a first spot between 6.50 and 9.00 ppm and a second spot between 1.50 and 4.50 ppm indicates the presence of a synthetic indole or indazole cannabinoid.
Type:
Application
Filed:
July 15, 2021
Publication date:
January 27, 2022
Applicant:
HOFSTRA UNIVERSITY
Inventors:
Ling HUANG, Michael Anthony MARINO, Brandy VOYER
Abstract: The present invention provides a method for detecting synthetic indole and indazole cannabinoids in a sample known or suspected to contain a synthetic indole or indazole cannabinoid in the absence of chromatography. A deuterated solvent is added to the solid sample, creating a suspension. The synthetic cannabinoid is detected in the suspension by analysis of the sample NMR spectrum. When one-dimensional proton NMR is used, detection of a first peak between 8.00 and 8.50 ppm and a second peak between 4.00 and 4.40 ppm, indicates the presence of a synthetic indole or indazole cannabinoid. When two-dimensional Correlation Spectroscopy (COSY) NMR is used, detection of a first spot between 6.50 and 9.00 ppm and a second spot between 1.50 and 4.50 ppm indicates the presence of a synthetic indole or indazole cannabinoid.
Type:
Grant
Filed:
April 25, 2014
Date of Patent:
August 10, 2021
Assignee:
Hofstra University
Inventors:
Ling Huang, Michael Anthony Marino, Brandy Voyer
Abstract: The present invention provides a method for detecting synthetic indole and indazole cannabinoids in a sample known or suspected to contain a synthetic indole or indazole cannabinoid. A deuterated solvent is added to the solid sample, creating a suspension. The suspension is mixed to release the cannabinoid from the solid sample. The suspension is subject to a NMR spectroscopy process to produce a sample NMR spectrum. The synthetic cannabinoid is detected in the suspension by analysis of the sample NMR spectrum. When one-dimensional proton NMR is used, detection of a first peak between 8.00 and 8.50 ppm and a second peak between 4.00 and 4.40 ppm, indicates the presence of a synthetic indole or indazole cannabinoid. When two-dimensional Correlation Spectroscopy (COSY) NMR is used, detection of a first spot between 6.50 and 9.00 ppm and a second spot between 1.50 and 4.50 ppm indicates the presence of a synthetic indole or indazole cannabinoid.
Type:
Application
Filed:
April 25, 2014
Publication date:
March 24, 2016
Applicant:
HOFSTRA UNIVERSITY
Inventors:
Ling HUANG, Michael Anthony MARINO, Brandy VOYER
Abstract: An ultrasound method and apparatus for classification of tissue in a region of interest in a body. The raw ultrasound return data is digitized and processed without the need for human visual analysis of pixel-scale video images. Tissue classification is done by correlation of the relative amount of energy in selected frequency bands of the power spectrum of the returned demodulated ultrasound data to that of known tissue samples.
Type:
Grant
Filed:
February 4, 1994
Date of Patent:
May 23, 1995
Assignees:
Long Island Jewish Medical Center, Hofstra University
Inventors:
Steven J. Evans, Scott L. Roth, Harold M. Hastings