Patents Assigned to Hokko Chemical Industry Co., Ltd.
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Publication number: 20140322775Abstract: It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.Type: ApplicationFiled: March 25, 2014Publication date: October 30, 2014Applicant: HOKKO CHEMICAL INDUSTRY CO., LTD.Inventors: Masanori Yamaguchi, Yuichi Kita, Tetsuya Mori, Kenji Kanbe, Akihiro Tomoda, Atsushi Takahashi, Wakako Ichikawa
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Patent number: 8715974Abstract: It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.Type: GrantFiled: March 8, 2013Date of Patent: May 6, 2014Assignee: Hokko Chemical Industry Co., Ltd.Inventors: Masanori Yamaguchi, Yuichi Kita, Tetsuya Mori, Kenji Kanbe, Akihiro Tomoda, Atsushi Takahashi, Wakako Ichikawa
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Patent number: 8604249Abstract: The invention relates to novel phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3 and Ar4 are as defined herein, and compositions including such phosphonium borate compounds in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex for use in carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and carbon-oxygen bond forming reactions.Type: GrantFiled: November 16, 2010Date of Patent: December 10, 2013Assignee: Hokko Chemical Industry Co., Ltd.Inventors: Shin Masaoka, Hideyuki Iwazaki
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Publication number: 20130196417Abstract: It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.Type: ApplicationFiled: March 8, 2013Publication date: August 1, 2013Applicant: HOKKO CHEMICAL INDUSTRY CO., LTD.Inventors: Masanori Yamaguchi, Yuichi Kita, Tetsuya Mori, Kenji Kanbe, Akihiro Tomoda, Atsushi Takahashi, Wakako Ichikawa
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Patent number: 8426629Abstract: Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). ArnR3-nP?O (1) ArnR3-nP (2) In formulae (1) and (2), Ar represents an aryl group such as a phenyl group, a phenyl group having a substituent, a heteroaromatic ring group, and a heteroaromatic ring group having a substituent; R represents an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having a substituent; and n represents an integer of 0 to 3.Type: GrantFiled: May 14, 2009Date of Patent: April 23, 2013Assignees: National University Corporation Okayama University, Asahi Kasei Chemicals Corporation, Hokko Chemical Industry Co., Ltd.Inventors: Hideo Tanaka, Manabu Kuroboshi, Tomotake Yano, Masakatsu Hoshino, Hiromu Kawakubo
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Patent number: 8409833Abstract: It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.Type: GrantFiled: February 25, 2010Date of Patent: April 2, 2013Assignee: Hokko Chemical Industry Co., Ltd.Inventors: Masanori Yamaguchi, Yuichi Kita, Tetsuya Mori, Kenji Kanbe, Akihiro Tomoda, Atsushi Takahashi, Wakako Ichikawa
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Patent number: 8383368Abstract: N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as Trichoderma hamatum AB 10282 strain (FERM BP-10623) or Trichoderma harzianum AB10283 strain (FERM BP-10624), in a culture medium supplemented with a carbon source other than chitin and chitin oligosaccharide and a nitrogen source to produce and accumulate N-acetyl-D-glucosamine in the culture medium and then collecting N-acetyl-D-glucosamine from the culture medium.Type: GrantFiled: November 11, 2010Date of Patent: February 26, 2013Assignee: Hokko Chemical Industry Co., Ltd.Inventors: Tetsuya Mori, Wakako Ichikawa, Yuichi Kita, Yasuyuki Tetsuka
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Patent number: 8314291Abstract: A plant with modified flower morphology is produced by suppressing a function of a transcription factor involved in determining the polarity of plants. More particularly, a plant with modified flower morphology is produced by the steps of obtaining a transformed cell by introducing a chimeric DNA in which a DNA encoding a transcription factor involved in determining the polarity and a functional peptide converting a transcription factor into a transcription repressor are fused; and regenerating a transformed plant from the transformed cell.Type: GrantFiled: August 4, 2008Date of Patent: November 20, 2012Assignees: University of Tsukuba, National Institute of Advanced Industrial Science and Technology, Hokko Chemical Industry Co., Ltd.Inventors: Michiyuki Ono, Teruhiko Terakawa, Masaru Takagi
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Patent number: 8163950Abstract: A silane containing a bulky hydrocarbon group or groups R therein and having the formula (III) R3?(x+y)(R1)x(R2)ySi(OR3) can be produced by reacting a silane of the formula (I) (R1)x(R2)ySiCl3?(x+y)(OR3) with a Grignard reagent of the formula (II) RMgX Further, a tri-organo-chlorosilane of the formula (XIIa) (R1)(R2)(R3)SiCl can be produced by reacting a tri-organo-silane of the formula (XIa) (R1)(R2)(R3)SiZ1 with hydrochloric acid. Furthermore, a tri-organo-monoalkoxysilane of the formula (XXIII) R3?(x+y)(R1)x(R2)ySi(OR3) can be produced when a silane of the formula (XXI) (R1)x(R2)ySiCl4?(x+y) is reacted with a Grignard reagent of the formula (XXII) RMgX with addition of and reaction with an alcohol or an epoxy compound during the reaction.Type: GrantFiled: July 19, 2011Date of Patent: April 24, 2012Assignees: Shin-Etsu Chemical Co., Ltd., Hokko Chemical Industry Co., Ltd.Inventors: Tadashi Bannou, Shin Masaoka, Yoshiki Hayakawa
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Publication number: 20120088936Abstract: In Suzuki Cross-Couplings, a palladium-containing perovskite-type composite oxide represented by the following general formula (1) is used as a catalyst for synthesis reaction: Ln2MyCu1-x-yPdxO4±???(1) wherein Ln represents elements composed of at least one essential element selected from La, Pr, Nd, Sm, Eu, and Gd and at least one optional element selected from Y, Ce, Yb, Ca, Sr, and Ba; M represents at least one element selected from Cr, Mn, Fe, Co, Ni, and Al; x, indicating an atomic proportion, is 0.001?x?0.4; y, indicating an atomic proportion, is 0?y?0.5; and ? indicates an oxygen excess amount or an oxygen deficiency amount.Type: ApplicationFiled: June 24, 2010Publication date: April 12, 2012Applicants: DAIHATSU MOTOR CO., LTD., HOKKO CHEMICAL INDUSTRY CO., LTD.Inventors: Kimiyoshi Kaneko, Hirohisa Tanaka
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Publication number: 20120052086Abstract: A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid ? antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid ? peptide into a wild type seed storage protein.Type: ApplicationFiled: November 7, 2011Publication date: March 1, 2012Applicant: Hokko Chemical Industry Co., Ltd.Inventors: Teruhiko Terakawa, Hisakazu Hasegawa, Yasushi Shimada, Atsushi Takahashi, Takeshi Kawarabayashi, Mikio Shoji
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Patent number: 8124809Abstract: The invention relates to methods for carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and/or carbon-oxygen bond forming reactions using phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3, and Ar4 are as defined herein in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex.Type: GrantFiled: April 1, 2011Date of Patent: February 28, 2012Assignee: Hokko Chemical Industry Co., Ltd.Inventors: Shin Masaoka, Hideyuki Iwazaki
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Publication number: 20110237799Abstract: The invention relates to methods for carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and/or carbon-oxygen bond forming reactions using phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3, and Ar4 are as defined herein in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex.Type: ApplicationFiled: April 1, 2011Publication date: September 29, 2011Applicant: HOKKO CHEMICAL INDUSTRY CO., LTD.Inventors: Shin MASAOKA, Hideyuki IWAZAKI
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Patent number: 8008521Abstract: A silane containing a bulky hydrocarbon group or groups R therein and having the formula (III) R3?(x+y)(R1)x(R2)ySi(OR3) can be produced by reacting a silane of the formula (I) (R1)x(R2)ySiCl3?(x+y)(OR3) with a Grignard reagent of the formula (II) RMgX Further, a tri-organo-chlorosilane of the formula (XIIa) (R1)(R2)(R3)SiCl can be produced by reacting a tri-organo-silane of the formula (XIa) (R1)(R2)(R3)SiZ1 with hydrochloric acid. Furthermore, a tri-organo-monoalkoxysilane of the formula (XXIII) R3?(x+y)(R1)x(R2)ySi(OR3) can be produced when a silane of the formula (XXI) (R1)x(R2)ySiCl4?(x+y) is reacted with a Grignard reagent of the formula (XXII) RMgX with addition of and reaction with an alcohol or an epoxy compound during the reaction.Type: GrantFiled: November 26, 2008Date of Patent: August 30, 2011Assignees: Hokko Chemical Industry Co., Ltd., Shin-Etsu Chemical Co., Ltd.Inventors: Tadashi Bannou, Shin Masaoka, Yoshiki Hayakawa
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Patent number: 7998723Abstract: N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as Trichoderma hamatum AB10282 strain (FERM BP-10623) or Trichoderma harzianum AB10283 strain (FERM BP-10624), in a culture medium supplemented with a carbon source other than chitin and chitin oligosaccharide and a nitrogen source to produce and accumulate N-acetyl-D-glucosamine in the culture medium and then collecting N-acetyl-D-glucosamine from the culture medium.Type: GrantFiled: July 14, 2006Date of Patent: August 16, 2011Assignee: Hokko Chemical Industry Co., Ltd.Inventors: Tetsuya Mori, Wakako Ichikawa, Yuichi Kita, Yasuyuki Tetsuka
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Publication number: 20110166389Abstract: The invention relates to novel phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3 and Ar4 are as defined herein, and compositions including such phosphonium borate compounds in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex for use in carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and carbon-oxygen bond forming reactions.Type: ApplicationFiled: November 16, 2010Publication date: July 7, 2011Applicant: HOKKO CHEMICAL INDUSTRY CO., LTD.Inventors: Shin MASAOKA, Hideyuki IWAZAKI
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Publication number: 20110065961Abstract: Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). ArnR3-nP?O (1) ArnR3-nP (2) In formulae (1) and (2), Ar represents an aryl group such as a phenyl group, a phenyl group having a substituent, a heteroaromatic ring group, and a heteroaromatic ring group having a substituent; R represents an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having a substituent; and n represents an integer of 0 to 3.Type: ApplicationFiled: May 14, 2009Publication date: March 17, 2011Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, ASAHI KASEI CHEMICALS CORPORATION, HOKKO CHEMICAL INDUSTRY CO., LTD.Inventors: Hideo Tanaka, Manabu Kuroboshi, Tomotake Yano, Masakatsu Hoshino, Hiromu Kawakubo
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Publication number: 20110059489Abstract: N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as Trichoderma hamatum AB 10282 strain (FERM BP-10623) or Trichoderma harzianum AB10283 strain (FERM BP-10624), in a culture medium supplemented with a carbon source other than chitin and chitin oligosaccharide and a nitrogen source to produce and accumulate N-acetyl-D-glucosamine in the culture medium and then collecting N-acetyl-D-glucosamine from the culture medium.Type: ApplicationFiled: November 11, 2010Publication date: March 10, 2011Applicant: Hokko Chemical Industry Co., Ltd.Inventors: Tetsuya Mori, Wakako Ichikawa, Yuichi Kita, Yasuyuki Tetsuka
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Publication number: 20100261238Abstract: It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to fonts a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.Type: ApplicationFiled: February 25, 2010Publication date: October 14, 2010Applicant: HOKKO CHEMICAL INDUSTRY CO., LTD.Inventors: MASANORI YAMAGUCHI, YUICHI KITA, TETSUYA MORI, KENJI KANBE, AKIHIRO TOMODA, ATSUSHI TAKAHASHI, WAKAKO ICHIKAWA
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Patent number: 7795505Abstract: A DNA encoding a phosphinothricin acetyltransferase protein obtained from Streptomyces sp. AB3534 strain is described which imparts a resistance to herbicides, particularly the herbicide phosphinothricin (PPT). Plants having a herbicide resistance are constructed by transforming a plant cell with DNA encoding the phosphinothricin acetyltransferase protein and then regenerating the transformed plant cell into a plant. A recombinant protein having the herbicide-resistant activity is also described.Type: GrantFiled: November 8, 2005Date of Patent: September 14, 2010Assignee: Hokko Chemical Industry Co., Ltd.Inventors: Hisakazu Hasegawa, Teruhiko Terakawa, Kiyoshi Hirazawa