Patents Assigned to Holaira, Inc.
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Patent number: 9675412Abstract: Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input. The coolable ablation assembly delivers energy through an inner surface of an airway to damage a target region of tissue such that the damaged target region has a maximum cross-sectional width radially separated from the inner surface of the airway.Type: GrantFiled: October 31, 2014Date of Patent: June 13, 2017Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 9668809Abstract: Systems, assemblies, and methods to treat pulmonary diseases are used to decrease nervous system input to distal regions of the bronchial tree within the lungs. Treatment systems damage nerve tissue to temporarily or permanently decrease nervous system input. The treatment systems are capable of heating nerve tissue, cooling the nerve tissue, delivering a flowable substance that cause trauma to the nerve tissue, puncturing the nerve tissue, tearing the nerve tissue, cutting the nerve tissue, applying pressure to the nerve tissue, applying ultrasound to the nerve tissue, applying ionizing radiation to the nerve tissue, disrupting cell membranes of nerve tissue with electrical energy, or delivering long acting nerve blocking chemicals to the nerve tissue.Type: GrantFiled: August 22, 2012Date of Patent: June 6, 2017Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 9662171Abstract: Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input. The system, delivery devices, and methods can damage tissue and manage scarring and stenosis.Type: GrantFiled: October 1, 2015Date of Patent: May 30, 2017Assignee: Holaira, Inc.Inventors: Steven C. Dimmer, Martin L. Mayse, Mark E. Deem, Hanson S. Gifford, III
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Patent number: 9649153Abstract: Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input.Type: GrantFiled: October 27, 2010Date of Patent: May 16, 2017Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 9649154Abstract: A system and method can be used to denervate at least a portion of a bronchial tree. An energy emitter of an instrument is percutaneously delivered to a treatment site and outputs energy to damage nerve tissue of the bronchial tree. The denervation procedure can be performed without damaging non-targeted tissue. Minimally invasive methods can be used to open airways to improve lung function in subjects with COPD, asthma, or the like. Different sections of the bronchial tree can be denervated while leaving airways intact to reduce recovery times.Type: GrantFiled: November 14, 2014Date of Patent: May 16, 2017Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 9539048Abstract: A method of reducing bronchial constriction in a subject includes delivering energy to create one or more lesions on a main bronchus so as to transect pulmonary nerves sufficiently to reduce bronchial constriction in a lung of the patient distal to the main bronchus.Type: GrantFiled: September 1, 2015Date of Patent: January 10, 2017Assignee: Holaira, Inc.Inventors: Edwin J. Hlavka, Lynn Elliott
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Patent number: 9398933Abstract: The present disclosure provides methods for improving drug efficacy in a patient having an obstructed airway in a lung. Such methods modulate nerve activity in the autonomic nervous system of a patient to reduce obstruction of an airway in a lung of the patient prior to administering a drug to the patient. These methods are especially useful in improving efficacies of bronchodilators in treating obstructive lung diseases, such as chronic obstructive pulmonary disease.Type: GrantFiled: December 27, 2013Date of Patent: July 26, 2016Assignee: Holaira, Inc.Inventor: Martin L. Mayse
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Patent number: 9339618Abstract: A method for controlling narrowing of at least one airway and associated apparatus are provided. The method includes positioning a needle-less injection assembly in an airway of a patient, and introducing a medication from at least one port of the needle-less injection assembly across an epithelium of a wall of the airway and into collagenous and smooth muscle layers of the airway wall such that the medication controls at least one mechanism of airway narrowing.Type: GrantFiled: November 5, 2012Date of Patent: May 17, 2016Assignee: Holaira, Inc.Inventors: Mark E. Deem, Hanson S. Gifford, III
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Publication number: 20160022351Abstract: A treatment system includes a fluid cooling supply system for chilling and delivering liquid coolant to a patient. The fluid cooling supply system includes a cooling device and a heat exchanger device. The heat exchanger device is biased to the cooling device and is in fluid communication with a treatment device in a patient. The fluid cooling supply system includes at least one biasing mechanism to provide a given biasing force between the heat exchanger device and the cooling device to effectuate and improve heat transfer. The liquid coolant may be circulated through an energy delivery device positioned in an airway of a patient to preserve tissue. The system is controlled to circulate liquid coolant at a given temperature and pressure for a selected amount of time during pulmonary treatment of a patient.Type: ApplicationFiled: March 13, 2014Publication date: January 28, 2016Applicant: Holaira, Inc.Inventors: Ryan Kaveckis, Edward S. Harshman, Martin L. Mayse, John Streeter, Kyle True, Richard C. Gunderson
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Patent number: 9149328Abstract: Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input. The system, delivery devices, and methods can damage tissue and manage scarring and stenosis.Type: GrantFiled: November 11, 2010Date of Patent: October 6, 2015Assignee: Holaira, Inc.Inventors: Steven C. Dimmer, Martin L. Mayse, Mark Deem, Hanson S. Gifford, III
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Patent number: 9125643Abstract: A method of reducing bronchial constriction in a subject includes delivering energy to create one or more lesions on a main bronchus so as to transect pulmonary nerves sufficiently to reduce bronchial constriction in a lung of the patient distal to the main bronchus.Type: GrantFiled: April 30, 2014Date of Patent: September 8, 2015Assignee: Holaira, Inc.Inventors: Edwin J. Hlavka, Lynn Elliott
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Patent number: 9017324Abstract: Systems, delivery devices, and methods to treat, ablate, damage, or otherwise affect tissue in an airway of a patient. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue while cooling non-targeted tissue to protect the non-targeted tissue from damage. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input.Type: GrantFiled: June 28, 2013Date of Patent: April 28, 2015Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 9005195Abstract: Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input.Type: GrantFiled: September 26, 2011Date of Patent: April 14, 2015Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 8961508Abstract: Systems, assemblies, and methods to treat pulmonary diseases are used to decrease nervous system input to distal regions of the bronchial tree within the lungs. Treatment systems damage nerve tissue to temporarily or permanently decrease nervous system input. The treatment systems are capable of heating nerve tissue, cooling the nerve tissue, delivering a flowable substance that cause trauma to the nerve tissue, puncturing the nerve tissue, tearing the nerve tissue, cutting the nerve tissue, applying pressure to the nerve tissue, applying ultrasound to the nerve tissue, applying ionizing radiation to the nerve tissue, disrupting cell membranes of nerve tissue with electrical energy, or delivering long acting nerve blocking chemicals to the nerve tissue.Type: GrantFiled: April 20, 2012Date of Patent: February 24, 2015Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 8961507Abstract: Systems, assemblies, and methods to treat pulmonary diseases are used to decrease nervous system input to distal regions of the bronchial tree within the lungs. Treatment systems damage nerve tissue to temporarily or permanently decrease nervous system input. The treatment systems are capable of heating nerve tissue, cooling the nerve tissue, delivering a flowable substance that cause trauma to the nerve tissue, puncturing the nerve tissue, tearing the nerve tissue, cutting the nerve tissue, applying pressure to the nerve tissue, applying ultrasound to the nerve tissue, applying ionizing radiation to the nerve tissue, disrupting cell membranes of nerve tissue with electrical energy, or delivering long acting nerve blocking chemicals to the nerve tissue.Type: GrantFiled: April 20, 2012Date of Patent: February 24, 2015Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 8932289Abstract: Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input.Type: GrantFiled: September 26, 2011Date of Patent: January 13, 2015Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 8911439Abstract: A system and method can be used to denervate at least a portion of a bronchial tree. An energy emitter of an instrument is percutaneously delivered to a treatment site and outputs energy to damage nerve tissue of the bronchial tree. The denervation procedure can be performed without damaging non-targeted tissue. Minimally invasive methods can be used to open airways to improve lung function in subjects with COPD, asthma, or the like. Different sections of the bronchial tree can be denervated while leaving airways intact to reduce recovery times.Type: GrantFiled: November 11, 2010Date of Patent: December 16, 2014Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 8821489Abstract: Systems, assemblies, and methods to treat pulmonary diseases are used to decrease nervous system input to distal regions of the bronchial tree within the lungs. Treatment systems damage nerve tissue to temporarily or permanently decrease nervous system input. The treatment systems are capable of heating nerve tissue, cooling the nerve tissue, delivering a flowable substance that cause trauma to the nerve tissue, puncturing the nerve tissue, tearing the nerve tissue, cutting the nerve tissue, applying pressure to the nerve tissue, applying ultrasound to the nerve tissue, applying ionizing radiation to the nerve tissue, disrupting cell membranes of nerve tissue with electrical energy, or delivering long acting nerve blocking chemicals to the nerve tissue.Type: GrantFiled: April 20, 2012Date of Patent: September 2, 2014Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 8808280Abstract: Systems, assemblies, and methods to treat pulmonary diseases are used to decrease nervous system input to distal regions of the bronchial tree within the lungs. Treatment systems damage nerve tissue to temporarily or permanently decrease nervous system input. The treatment systems are capable of heating nerve tissue, cooling the nerve tissue, delivering a flowable substance that cause trauma to the nerve tissue, puncturing the nerve tissue, tearing the nerve tissue, cutting the nerve tissue, applying pressure to the nerve tissue, applying ultrasound to the nerve tissue, applying ionizing radiation to the nerve tissue, disrupting cell membranes of nerve tissue with electrical energy, or delivering long acting nerve blocking chemicals to the nerve tissue.Type: GrantFiled: April 20, 2012Date of Patent: August 19, 2014Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer
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Patent number: 8777943Abstract: Systems, delivery devices, and methods to treat, ablate, damage, or otherwise affect tissue in an airway of a patient. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue while cooling non-targeted tissue to protect the non-target tissue from damage. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input.Type: GrantFiled: June 28, 2013Date of Patent: July 15, 2014Assignee: Holaira, Inc.Inventors: Martin L. Mayse, Steven C. Dimmer