Patents Assigned to HOMOLOGY MEDICINES, INC.
  • Adeno-associated virus compositions for restoring PAH gene function and methods of use thereof
    Patent number: 12203094
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can restore phenylalanine hydroxylase (PAH) gene function in cell. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: January 21, 2025
    Assignee: Homology Medicines, Inc.
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, James Anthony McSwiggen, Jaime Michelle Prout, Danielle Lauren Sookiasian
  • Adeno-associated virus compositions for restoring PAH gene function and methods of use thereof
    Patent number: 12076420
    Abstract: Provided herein are recombinant adeno-associated virus (rAAV) compositions that can restore phenylalanine hydroxylase (PAH) gene function in cells, and methods for using the same to treat diseases associated with reduction of PAH gene function (e.g., PKU). Also provided are nucleic acids, vectors, packaging systems, and methods for making the adeno-associated virus compositions.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: September 3, 2024
    Assignee: Homology Medicines, Inc.
    Inventors: Jason Boke Wright, Danielle Lauren Sookiasian, Thia Baboval St. Martin, Omar Francone, Albert Barnes Seymour
  • Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
    Patent number: 12064486
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: August 20, 2024
    Assignee: Homology Medicines, Inc.
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin
  • Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
    Patent number: 11951183
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: April 9, 2024
    Assignee: HOMOLOGY MEDICINES, INC.
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin
  • Methods of treating phenylketonuria
    Patent number: 11952585
    Abstract: Provided herein are methods of treating a subject having a disease or disorder associated with a PAH gene mutation. The methods generally comprise administering to the subject a therapeutically effective does of a recombinant adeno-associated virus (rAAV) that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell and thereby restore PAH gene function in the subject.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: April 9, 2024
    Assignee: HOMOLOGY MEDICINES, INC.
    Inventors: Omar L. Francone, Deborah A. Kinch, Diana Lamppu, Albert Barnes Seymour, Teresa Leah Wright
  • Adeno-associated virus compositions for restoring F8 gene function and methods of use thereof
    Patent number: 11891619
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can restore F8 gene function in a cell without co-transducing or co-administering an exogenous nuclease or a nucleotide sequence that encodes an exogenous nuclease. Also provided are methods of using the AAV compositions to correct an F8 gene mutation and/or treat a disease or disorder associated with an F8 gene mutation. Packaging systems for making the adeno-associated virus compositions are also provided.
    Type: Grant
    Filed: March 10, 2022
    Date of Patent: February 6, 2024
    Assignees: City of Hope, Homology Medicines, Inc.
    Inventors: Saswati Chatterjee, Laura Jane Smith, Jeff Lynn Ellsworth, Hillard Rubin, Jason Boke Wright, James Anthony McSwiggen
  • Adeno-associated virus compositions for restoring F8 gene function and methods of use thereof
    Patent number: 11306329
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can restore F8 gene function in a cell without co-transducing or co-administering an exogenous nuclease or a nucleotide sequence that encodes an exogenous nuclease. Also provided are methods of using the AAV compositions to correct an F8 gene mutation and/or treat a disease or disorder associated with an F8 gene mutation. Packaging systems for making the adeno-associated virus compositions are also provided.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: April 19, 2022
    Assignees: CITY OF HOPE, HOMOLOGY MEDICINES, INC.
    Inventors: Saswati Chatterjee, Laura Jane Smith, Jeff Lynn Ellsworth, Hillard Rubin, Jason Boke Wright, James Anthony McSwiggen
  • Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
    Patent number: 10610606
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: April 7, 2020
    Assignee: HOMOLOGY MEDICINES, INC.
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin