Abstract: A motorcycle engine mounting structure having a head tube (23), a main frame pipe (21) extended rearwardly from the head tube, and an engine (60). In order to increase the freedom of design for mounting an engine and to ensure a radiator mounting space, a pair of supporting members (40, 50; 240, 250) are suspended from the front part of the main frame (21), and the engine (60) is supported in the front part through the supporting members.