Abstract: A method for co-producing blister copper by enriching germanium and indium from a copper sulfide ore comprises: mixing a copper sulfide ore containing germanium and indium, a reducing agent and a fluxing agent in proportion and then grinding; subjecting the mixture to reduction matte smelting to obtain volatile smoke containing germanium and indium and copper matte respectively; subjecting the copper matte to oxygen-enriched blowing to volatilize germanium and indium, so as to obtain the blister copper and volatile smoke containing germanium and indium respectively; and oxidizing fumes discharged from bag dust collection by ozone, and then absorbing them by spraying alkali liquor to reach up-to-standard discharge. In the reduction smelting stage, the volatilization rate of germanium and indium is more than 70%; and in the copper matte oxygen-enriched blowing stage, the volatilization rate of germanium and indium is more than 25%.