Patents Assigned to Horizon Biotechnologies, Inc.
  • Affinity maturation by competitive selection
    Publication number: 20020155502
    Abstract: The present invention provides a method of selecting binding pair members with enhanced binding affinity for the cognate binding partner relative to a reference binding pair member. In particular, the invention provides methods of selecting antibodies with enhanced affinity for an antigen relative to a reference antibody. This process, “affinity maturation”, thereby provides antibodies with superior binding capabilities.
    Type: Application
    Filed: October 30, 2001
    Publication date: October 24, 2002
    Applicant: Horizon Biotechnologies, Inc.
    Inventors: Robert F. Balint, Jeng-Horng Her, James W. Larrick