Patents Assigned to Hormos Medical Corporation
  • Method for enhancing the bioavailability of ospemifene
    Patent number: 9855224
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: January 2, 2018
    Assignee: HORMOS MEDICAL CORPORATION
    Inventor: Markku Anttila
  • Solid formulations of ospemifene
    Patent number: 8642079
    Abstract: This invention relates to a solid drug formulation comprising granulates containing a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, in combination with one or more intra-granular excipients.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: February 4, 2014
    Assignee: Hormos Medical Corporation
    Inventors: Veli-Matti Lehtola, Kaija Halonen
  • METHOD FOR THE TREATMENT OR PREVENTION OF LOWER URINARY TRACT SYMPTOMS
    Publication number: 20130345313
    Abstract: This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 19, 2013
    Publication date: December 26, 2013
    Applicant: Hormos Medical Corporation
    Inventors: Risto Santti, Tomi Streng
  • METHOD FOR ENHANCING THE BIOAVAILABILITY OF OSPEMIFENE
    Publication number: 20120270952
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Application
    Filed: July 6, 2012
    Publication date: October 25, 2012
    Applicant: Hormos Medical Corporation
    Inventor: Markku ANTTILA
  • Method for enhancing the bioavailablity of ospemifene
    Patent number: 8236861
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: August 7, 2012
    Assignee: Hormos Medical Corporation
    Inventor: Markku Anttila
  • Lignan derivatives
    Patent number: 7528166
    Abstract: Novel phenolic esters of lignans, and pharmaceutical compositions, dietary supplements, and food products containing these esters.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: May 5, 2009
    Assignee: Hormos Medical Corporation
    Inventors: Patrik Eklund, Mervi Hiilovaara-Teijo, Arja Kalapudas, Lauri Kangas, Anna Lindholm, Rainer Sjohölm, Marja Södervall, Mikko Unkila
  • Method for treatment or prevention of androgen deficiency
    Publication number: 20060293294
    Abstract: This invention relates to a method for the treatment or prevention of androgen deficiency in a male individual by administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture, metabolite or a pharmaceutically acceptable salt thereof. Furthermore, the invention concerns methods for the treatment or prevention of diseases or disorders caused by androgen deficiency.
    Type: Application
    Filed: July 18, 2005
    Publication date: December 28, 2006
    Applicant: HORMOS MEDICAL CORPORATION
    Inventors: Taru Blom, Janne Komi, Risto Lammintausta
  • Method for the production of a phenolic substance from wood
    Patent number: 7153982
    Abstract: A method for the production of hydroxymatairesinol or a hydroxymatairesinol complex from wood, including the steps of a) extracting finely divided wood material with a polar solvent, b) optionally concentrating the extract by separating at least part of the solvent, c) adding to the extract an agent able to form a complex with hydroxymatairesinol, d) precipitating the hydroxymatairesinol complex, and optionally e) releasing the hydroxymatairesinol from the complex.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: December 26, 2006
    Assignee: Hormos Medical Corporation
    Inventors: Seppo Parhi, Mervi Puska, Arja Kalapudas, Helena Korte, Petri Hukka
  • Method for prevention or treatment of diseases or disorders related to excessive formation of vascular tissue or blood vessels
    Publication number: 20060154870
    Abstract: This invention concerns a method for treating or preventing a disease or disorder related to excessive formation of vascular tissue or blood vessels in a patient, said method comprising administering to said patient an agent affecting the NPY Y2 receptor.
    Type: Application
    Filed: March 10, 2006
    Publication date: July 13, 2006
    Applicant: Hormos Medical Corporation
    Inventors: Markku Koulu, Jukka Tuohimaa, Ullamari Pesonen, Jaana Kallio, Matti Karvonen
  • Method for the preparation of lariciresinol cyclolariciresinol and secoisolariciresinol
    Patent number: 7049449
    Abstract: A method for the preparation of lariciresinol, cyclolariciresinol or secoisolariciresinol, which method includes the steps of a) reducing hydroxymatairesinol to give 7-hydroxy-secoisolariciresinol, and b) subjecting the 7-hydroxy-secoisolariciresinol obtained in step a) to i) cyclization to give lariciresinol, or ii) cyclization to give cyclolariciresinol, or iii) catalytic hydrogenolysis to give secoisolariciresinol.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: May 23, 2006
    Assignee: Hormos Medical Corporation
    Inventors: Rainer Sjöholm, Patrik Eklund, Jyri-Pekka Mikkola
  • Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women
    Patent number: 6984665
    Abstract: This invention relates to a method for inhibition of skin atrophy, or epithelial or mucosal atrophy in women, or to a method for treatment or prevention of symptoms related to said atrophy, said method comprising administering to the woman an effective amount of the compound of formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: January 10, 2006
    Assignee: Hormos Medical Corporation
    Inventors: Taru Blom, Paula Grönroos, Kaija Halonen, Pirkko Härkönen
  • Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women
    Publication number: 20050272825
    Abstract: This invention relates to a method for inhibition of skin atrophy, or epithelial or mucosal atrophy in women, or to a method for treatment or prevention of symptoms related to said atrophy, said method comprising administering to the woman an effective amount of the compound of formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof.
    Type: Application
    Filed: August 11, 2005
    Publication date: December 8, 2005
    Applicant: Hormos Medical Corporation
    Inventors: Taru Blom, Paula Gronroos, Kaija Halonen, Pirkko Harkonen
  • Method for treatment or prevention of osteoporosis in individuals with high bone turnover
    Publication number: 20050187302
    Abstract: This invention relates to a method for the treatment or prevention of osteoporosis in an individual suffering from increased bone turnover, said method comprising administering to said individual an effective amount of a therapeutically active compound, which is a selective estrogen receptor modulator of the triphenylalkene or triphenylalkane structure.
    Type: Application
    Filed: February 23, 2004
    Publication date: August 25, 2005
    Applicant: Hormos Medical Corporation
    Inventors: Taru Blom, Lauri Kangas, Risto Lammintausta
  • Solid formulations of ospemifene
    Publication number: 20050187301
    Abstract: This invention relates to a solid drug formulation comprising granulates containing a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, in combination with one or more intra-granular excipients.
    Type: Application
    Filed: February 23, 2004
    Publication date: August 25, 2005
    Applicant: Hormos Medical Corporation
    Inventors: Veli-Matti Lehtola, Kaija Halonen
  • Method for enhancing the bioavailability of ospemifene
    Publication number: 20050182143
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Application
    Filed: February 13, 2004
    Publication date: August 18, 2005
    Applicant: Hormos Medical Corporation
    Inventor: Markku Anttila
  • Method for reducing overproduction of neuropeptide Y in an individual
    Publication number: 20050107327
    Abstract: This invention relates to method for reducing the overproduction of neuropeptide Y (NPY) in an individual, said method being aimed to modulate an overactive NPY system in said individual. The overproduction is either counteracted by administering an antagonist, or in case the individual has a polymorphism comprising the substitution of the position 7 leucine for proline in the signal peptide part of the preproNPY, said individual is subjected to a method aimed to reduce or prevent expression of the mutated allele causing said polymorphism.
    Type: Application
    Filed: October 22, 2004
    Publication date: May 19, 2005
    Applicant: HORMOS MEDICAL CORPORATION
    Inventors: Markku Koulu, Matti Karvonen, Ullamari Pesonen, Matti Uusitupa, Jaana Kallio
  • Method for the preparation of 2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}ethanol and its isomers
    Patent number: 6891070
    Abstract: A new method for the preparation of a selective estrogen receptor modulator and its isomers. Also disclosed is the preparation of new intermediates and their use in the preparation of the selective estrogen receptor modulator.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: May 10, 2005
    Assignee: Hormos Medical Corporation
    Inventors: Arja Kalapudas, Marja Södervall
  • Method for the preparation of matairesinol
    Publication number: 20050080299
    Abstract: A method for the preparation of matairesinol from hydroxymatairesinol, either by (i) catalytic hydrogenolysis of the hydroxy group in 7-position of hydroxymatairesinol, where the reaction is carried out in a suitable solvent as a pressurized hydrogenolysis, or (ii) reduction of hydroxymatairesinol, where the reduction is carried out as a hydrogen transfer reaction from a hydrogen donor in the presence of a catalyst.
    Type: Application
    Filed: January 2, 2003
    Publication date: April 14, 2005
    Applicant: Hormos Medical Corporation
    Inventors: Rainer Sjoholm, Patrik Eklund, Jyri Mikkola, Reko Lehtila, Marja Sodervale, Arja Kalapudas
  • Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women
    Publication number: 20030036566
    Abstract: This invention relates to a method for inhibition of skin atrophy, or epithelial or mucosal atrophy in women, or to a method for treatment or prevention of symptoms related to said atrophy, said method comprising administering to the woman an effective amount of the compound of formula (I) 1
    Type: Application
    Filed: June 6, 2002
    Publication date: February 20, 2003
    Applicant: Hormos Medical Corporation
    Inventors: Taru Blom, Paula Gronroos, Kaija Halonen, Pirkko Harkonen