Abstract: The invention relates to a dispensing device for dispensing a fluid product. The device includes a dispensing end; an attachment end; and a dispensing valve provided between the attachment end and the dispensing end and formed by a flexible member and a rigid member. The dispensing valve is actuatable between an open position in which a dispensing channel is formed between the flexible member and the rigid member, and a closed position in which the dispensing channel is closed. The dispensing valve includes a first valve portion and a second valve portion. The second valve portion is located closer to the dispensing end than the first valve portion. The dispensing valve is configured such that a greater biasing force is applied onto the rigid member by the flexible member in the first valve portion than in the second valve portion when the dispensing valve is in the closed position.

Abstract: The invention relates to a novel hyperosmolar composition of hyaluronic acid for the use thereof in the treatment of corneal oedema.

Abstract: The device includes a dispensing end; an attachment end; and a dispensing valve provided between the attachment end and the dispensing end and formed by a flexible member and a rigid member. The dispensing valve is actuatable between an open position in which a dispensing channel is formed between the flexible member and the rigid member, and a closed position in which the dispensing channel is closed. The dispensing valve includes a first valve portion and a second valve portion. The second valve portion is located closer to the dispensing end than the first valve portion. The dispensing valve is configured such that a greater biasing force is applied onto the rigid member by the flexible member in the first valve portion than in the second valve portion when the dispensing valve is in the closed position.

Abstract: The device (100) for packaging and dispensing a product, liquid or in gel form, optionally for an ophthalmic application, comprises a container (1) containing the product to be dispensed by a dispensing head (7), as well as a refilling and filtering assembly for the air entering the container (1) after a dispensing, the dispensing head delimiting one or more dosing chambers (5) and including at its end a flexible part (7) which can be actuated to allow the release of the dose of product in a compressed state of said chamber (5). The air refilling and filtering assembly has a sterilizing filter (11) which cooperates with a check valve (12), this assembly (11, 12) being typically located in a central or inner portion of the head (7). The supply of outside air is accomplished by means of a channel (16) leading to an outer orifice (10) able to be obturated by a cover (15).

Abstract: The present invention relates to a novel pharmaceutical composition comprising doxycycline for topical application, in particular to the eye and eyelids. The invention also relates to this topical composition for use in the treatment of bacterial infections of the skin and mucous membranes.

Abstract: The invention relates to a novel hyperosmolar composition of hyaluronic acid for the use thereof in the treatment of conical oedema.

Abstract: The device for packaging and dispensing a product comprises a container (1) intended to contain in a sterile manner the product to be packaged and dispensed in the form of calibrated doses or drops by means of a dispensing accessory equipped with a mouthpiece (4) of the type having a flexible part (5), said accessory forming a dosing chamber (7) for the dispensing of the calibrated drop. An outer wall (8) of the mouthpiece delimits a space (18) equipped with one or more openings (19), the end of said mouthpiece (4) including a central channel (13) allowing the dispensing of the calibrated drop, associated with one or more lateral channels (11) leading into the space (18). A cover (14) equipped with an inner skirt (15), in the mounted state, creates an overpressure so as to eliminate any residual drop (10) which can subsist in the mouthpiece (4) at the end. Application to the dispensing of doses of sterile products, particularly of drops in ophthalmology.

Abstract: The device (100) for packaging and dispensing a product, liquid or in gel form, optionally for an ophthalmic application, comprises a container (1) containing the product to be dispensed by a dispensing head (7), as well as a refilling and filtering assembly for the air entering the container (1) after a dispensing, the dispensing head delimiting one or more dosing chambers (5) and including at its end a flexible part (7) which can be actuated to allow the release of the dose of product in a compressed state of said chamber (5). The air refilling and filtering assembly has a sterilizing filter (11) which cooperates with a check valve (12), this assembly (11, 12) being typically located in a central or inner portion of the head (7). The supply of outside air is accomplished by means of a channel (16) leading to an outer orifice (10) able to be obturated by a cover (15).

Abstract: The present invention relates to a sterile and/or decontaminated composition for topical use, including hyaluronic acid at a concentration of greater than or equal to 0.1 wt % relative to the total weight of the composition, at least one skin wound healing agent, optionally at least one plant extract, and at least one solvent. The invention also relates to a unit including such a composition, to a method for preparing such a composition, and to the uses thereof.

Abstract: Device for packaging and dispensing drops of a substance for ophthalmic use, generally fluid, semi-fluid or in suspension, emulsion or oily solution, including a dispensing accessory with a first valve made of an elastomer material that allows the substance to pass through when the dispensing accessory is stressed, without allowing outside air to pass through in the opposite direction when the dispensing accessory is relaxed, characterized in that the first valve is covered by a layer of Parylene.

Abstract: The present invention relates to an oil-in-water emulsion comprising at least one mucomimetic polymer, at least one lipid of phospholipid type, at least one lipid other than the phospholipid, at least one stabilizing polymer, and a hydrophilic liquid, to an emulsion comprising an aqueous phase that contains at least one stabilizing polymer and at least one mucomimetic polymer, and an oily phase that contains at least one lipid of phospholipid type and a lipid other than the phospholipid, to a medicament comprising one of these emulsions, and to the use of one of these emulsions as an agent for restoring and/or replacing the lachrimal film or as a carrier for an active compound.

Abstract: Device for packaging and dispensing drops of a substance for ophthalmic use, generally fluid, semi-fluid or in suspension, emulsion or oily solution, comprising a dispensing accessory (7) with a first valve (5) made of an elastomer material that allows the substance to pass through when the dispensing accessory (7) is stressed, without allowing outside air to pass through in the opposite direction when the dispensing accessory (7) is relaxed, characterized in that the first valve (5) is covered by a layer of Parylene.

Abstract: The present invention relates to an oil-in-water emulsion comprising at least one mucomimetic polymer, at least one lipid of phospholipid type, at least one lipid other than the phospholipid, at least one stabilizing polymer, and a hydrophilic liquid, to an emulsion comprising an aqueous phase that contains at least one stabilizing polymer and at least one mucomimetic polymer, and an oily phase that contains at least one lipid of phospholipid type and a lipid other than the phospholipid, to a medicament comprising one of these emulsions, and to the use of one of these emulsions as an agent for restoring and/or replacing the lachrimal film or as a carrier for an active compound.

Abstract: The present invention relates to a sterile and/or decontaminated composition for topical use, including hyaluronic acid at a concentration of greater than or equal to 0.1 wt % relative to the total weight of the composition, at least one skin wound healing agent, optionally at least one plant extract, and at least one solvent. The invention also relates to a unit including such a composition, to a method for preparing such a composition, and to the uses thereof.