Patents Assigned to HOSPICES CIVILS DE LYON (HCL)
  • Patent number: 11180806
    Abstract: The present invention relates to a process for determining in vitro the immune status of an individual according to which: (a) a blood sample from the individual is provided, (b) at least two reagents specific to at least two products of expression of at least two target genes are provided; (c) the expression of said at least two target genes is determined, and (d) the expression of said at least two target genes respectively is compared with a reference expression, with a change in the expression of said at least two target genes relative to their reference expression indicating that the individual's immune status has changed, and a correlation between the expression of said at least two target genes with their reference expression indicating that the individual's immune status is normal; as well as a kit for determining said immune status of the individual.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: November 23, 2021
    Assignees: BIOMERIEUX, HOSPICES CIVILS DE LYON (HCL)
    Inventors: Fanny Davin, Alain Lepape, Guillaume Monneret, Florence Frager
  • Publication number: 20180312921
    Abstract: The present invention relates to a process for determining in vitro the immune status of an individual according to which: (a) a blood sample from the individual is provided, (b) at least two reagents specific to at least two products of expression of at least two target genes are provided; (c) the expression of said at least two target genes is determined, and (d) the expression of said at least two target genes respectively is compared with a reference expression, with a change in the expression of said at least two target genes relative to their reference expression indicating that the individual's immune status has changed, and a correlation between the expression of said at least two target genes with their reference expression indicating that the individual's immune status is normal; as well as a kit for determining said immune status of the individual.
    Type: Application
    Filed: April 24, 2018
    Publication date: November 1, 2018
    Applicants: BIOMERIEUX, HOSPICES CIVILS DE LYON (HCL)
    Inventors: Fanny DAVIN, Alain LEPAPE, Guillaume MONNERET, Florence FRAGER
  • Patent number: 9110079
    Abstract: A method and a kit for establishing an in vitro prognosis on a patient exhibiting SIRS, the method comprising: (i) measuring the level of expression of the CX3CR1 gene in vitro from the biological material of a patient sample by bringing into contact said sample with a specific reagent of the CX3CR1 gene; and (ii) comparing the expression level of the CX3CR1 gene of the patient to a predetermined expression threshold; wherein (iii) if the expression level of the CX3CR1 gene of the patient is less than the predetermined expression threshold, the survival prognosis of the patient is poor, and if the expression level of the CX3CR1 gene of the patient is greater than the predetermined expression threshold, the survival prognosis of the patient is good.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: August 18, 2015
    Assignees: BIOMERIEUX, HOSPICES CIVILS DE LYON (HCL)
    Inventors: Marie-Angélique Cazalis, Alexandre Pachot, Sylvie Tissot, Guillaume Monneret
  • Publication number: 20130316930
    Abstract: The present invention relates to a process for determining in vitro the immune status of an individual according to which: (a) a blood sample from the individual is provided, (b) at least two reagents specific to at least two products of expression of at least two target genes are provided; (c) the expression of said at least two target genes is determined, and (d) the expression of said at least two target genes respectively is compared with a reference expression, with a change in the expression of said at least two target genes relative to their reference expression indicating that the individual's immune status has changed, and a correlation between the expression of said at least two target genes with their reference expression indicating that the individual's immune status is normal; as well as a kit for determining said immune status of the individual.
    Type: Application
    Filed: January 27, 2012
    Publication date: November 28, 2013
    Applicants: HOSPICES CIVILS DE LYON (HCL), BIOMERIEUX
    Inventors: Fanny Davin, Alain Lepape, Guillaume Monneret, Florence Frager
  • Publication number: 20120077693
    Abstract: A method and a kit for establishing an in vitro prognosis on a patient exhibiting SIRS, the method comprising: (i) measuring the level of expression of the CX3CR1 gene in vitro from the biological material of a patient sample by bringing into contact said sample with a specific reagent of the CX3CR1 gene; and (ii) comparing the expression level of the CX3CR1 gene of the patient to a predetermined expression threshold; wherein (iii) if the expression level of the CX3CR1 gene of the patient is less than the predetermined expression threshold, the survival prognosis of the patient is poor, and if the expression level of the CX3CR1 gene of the patient is greater than the predetermined expression threshold, the survival prognosis of the patient is good.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 29, 2012
    Applicants: HOSPICES CIVILS DE LYON (HCL), BIOMERIEUX
    Inventors: Marie-Angélique CAZALIS, Alexandre PACHOT, Sylvie TISSOT, Guillaume MONNERET
  • Publication number: 20110250592
    Abstract: A method for determining a patient's susceptibility of contracting a nosocomial infection that includes obtaining a biological sample from the patient and extracting biological material from the biological sample; preparing a specific reagent of an expression product of at least one target gene selected from S100A9 and S100A8 target genes; and determining the expression of at least one of the target genes S100A9 and S100A8, where overexpression relative to a specified threshold value indicates susceptibility of contracting a nosocomial infection.
    Type: Application
    Filed: January 18, 2010
    Publication date: October 13, 2011
    Applicants: HOSPICES CIVILS DE LYON (HCL), BIOMERIEUX
    Inventors: Marie-Angelique Cazalis, Alain Lepape, Guillaume Monneret, Bruno Mougin, Alexandre Pachot