Abstract: The method comprising acquiring and analyzing by computer means image information of video sequences of two or more dimensions obtained from contrast-enhanced signals, for example ultrasound, coherence tomography, fluorescence images, or Magnetic Resonance Imaging, of a body part or tissue, for example of an organ, of a living subject; detecting events from said information of video sequences; selecting a Region of Interest of said body part or tissue; computing a first graph representative of a local vascular network of said image information of video sequences in which the edges of the graph are estimated by the temporal relationship among spatially remote signals of said image information of video sequences within a set of video sequences; and using said graph for assessment of vascular networks.

Abstract: The present invention discloses soluble isoforms of CD5 and CD6, which are scavenger-like lymphocyte receptors, for use in the prophylaxis or therapy of disorders or in therapeutic interventions, which would benefit from an exacerbated immune response to either endogenous or exogenous antigens, resulting from a decrease in lymphocyte subpopulations with regulatory functions and/or increase in lymphocyte subpopulations with effector functions. Special disorders are cell growth disorders, and chronic infections of bacterial, viral, fungal or parasitic origin. The invention also provides animal models for the study and the prophylaxis/treatment of autoimmune diseases, cancer, and chronic infections.

Abstract: The method comprising acquiring and analysing by computer means image information of video sequences of two or more dimensions obtained from contrast-enhanced signals, for example ultrasound, coherence tomography, fluorescence images, or Magnetic Resonance Imaging, of a body part or tissue, for example of an organ, of a living subject; detecting events from said information of video sequences; selecting a Region of Interest of said body part or tissue; computing a first graph representative of a local vascular network of said image information of video sequences in which the edges of the graph are estimated by the temporal relationship among spatially remote signals of said image information of video sequences within a set of video sequences; and using said graph for assessment of vascular networks.

Abstract: The invention provides novel healthy kidney biomarkers useful in the monitoring of renal function and in the prognosis and diagnosis of renal dysfunctions, especially those related to graft rejection. The invention further relates to methods for aiding in the evaluation, and design of personalized therapies in transplantation nephrology.

Abstract: The present invention discloses soluble isoforms of CD5 and CD6, which are scavenger-like lymphocyte receptors, for use in the prophylaxis or therapy of disorders or in therapeutic interventions, which would benefit from an exacerbated immune response to either endogenous or exogenous antigens, resulting from a decrease in lymphocyte subpopulations with regulatory functions and/or increase in lymphocyte subpopulations with effector functions. Special disorders are cell growth disorders, and chronic infections of bacterial, viral, fungal or parasitic origin. The invention also provides animal models for the study and the prophylaxis/treatment of autoimmune diseases, cancer, and chronic infections.

Abstract: The present invention belongs to the field of vaccines for the prevention and prophylaxis against malaria, more specifically it relates to exosomes isolated from reticulocytes infected with Plasmodium sp., to methods for obtaining them and to the use thereof for the prevention and prophylaxis against malaria as well as to its use for the discovery and identification of novel Plasmodium antigens. The invention also refers to artificial exosomes comprising Plasmodium sp. antigens. Finally, the invention refers to specific antigens discovered by means of the exosomes obtained from reticulocytes infected with Plasmodium sp.

Abstract: The present invention provides a therapeutic tool against intimal hyperplasia consisting of the use of Kv1.3 channel blocking substances, able to selectively stop cell migration and multiplication of VSMCs.

Abstract: The present invention refers to pharmaceutical compositions comprising the soluble CD5 ectodomain and its use for the prevention and/or treatment of fungal infections and/or fungal sepsis, as well as inflammatory disorders of fungal origin.

Abstract: Equipment for infrared vision of anatomical structures applicable to assist the physicians in endoscopic, fetoscopic or laparoscopic operations and methods for signal processing to enhance said vision, comprising two units that work together: a multimodal or multispectral imaging unit, constituted by a device comprising an endoscope or fetoscope or laparoscope, and additional optical systems to acquire multimodal images of the interior of the patient's body; and an image processing unit, to which said images are transferred, comprising processing devices with a navigation interface which process said images and display the patient's enhanced anatomical map image and the endoscope location, equipped with hardware and software that apply at least five different vision-enhancing methods, namely normalization, segmentation, tracking, mapping and fusion.

Abstract: The present invention provides a therapeutic tool against intimal hyperplasia consisting of the use of Kv1.3 channel blocking substances, able to selectively stop cell migration and multiplication of VSMCs.

Abstract: The present invention comprises the use of WNT1 as a biomarker in the monitoring, prognosis and/or in the diagnosis of chronic nephropathies. It provides in vitro prognostic and diagnostic methods and kits for its implementation. The present invention also comprises the use of WNT1 in screening active ingredients for the manufacture of a drug for therapies for chronic nephropathies and a method for conducting said screening.

Abstract: The present invention refers to pharmaceutical compositions comprising the soluble CD5 ectodomain and its use for the prevention and/or treatment of fungal infections and/or fungal sepsis, as well as inflammatory disorders of fungal origin.

Abstract: The invention relates to the use of an antibody or a fragment thereof, specific against substance P, for the manufacture of a medicament for therapeutic treatment of a cancer expressing NK1 receptor and/or a ErbB receptor family member (i.e. the epidermal growth factor receptors family), by direct administration to a mammal, including a human. The administration of an antibody against substance P to a panel of breast cancer cell lines, inhibits HER2 activation and expression, causing a downregulation of different genes involved in cell cycle progression, like cyclin D1, cyclin E, cdk4 and cdk2. A decrease in proliferation and an arrest in G1 phase of cell cycle are observed. On the other hand, the antibody causes an induction of apoptosis.