Abstract: In one aspect, the present disclosure provides methods of inhibiting STAT3 in a cell comprising contacting the cell with a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure provides methods of using of the compounds disclosed herein for the treatment of cancer.
Type:
Application
Filed:
July 19, 2019
Publication date:
June 2, 2022
Applicants:
Board of Regents, The University of Texas System, The Methodist Hospital dba Houston Methodist Hospital
Inventors:
David John TWEARDY, Ren KONG, Uddalak BHARADWAJ, Moses Makokha KASEMBELI, Stephen T. C. WONG
Abstract: The invention provides methods and compositions that improve the success of organ transplantation. The methods and compositions are directed to exposing a desired organ to stem cells prior to, during, and/or after transplantation. In one embodiment, the stem cells reduce the deleterious effects of ischemia on an organ designated to be harvested for transplantation or that has been harvested for transplantation. In another embodiment in which an organ designated for transplantation is perfused ex vivo, the method involves reducing ischemic reperfusion injury by perfusing the organ with a medium that contains stem cells.
Abstract: The present invention relates to a polymer scaffold design and method for treating segmental long bone defects without amputation that permits permanent regrowth of bone in the area of the segmental defect, without external fixation or other problems inherent in current systems. The polymer scaffold is preferably made from a poly(ester urea) polymer and includes an outer shell, sized to fit over a segmental defect in a bone, and a collagen containing material. In some embodiments, the collagen containing material is placed in a polymer insert sized to fit within the segmental bone defect and within said outer shell. In some embodiments, the outer shell may contain struts running longitudinal struts along the inside surface of the outer shell. In some of these embodiments, the insert will have a corresponding set of grooves sized to receive the struts.
Type:
Grant
Filed:
May 13, 2015
Date of Patent:
February 19, 2019
Assignees:
The University of Akron, Houston Methodist Hospital
Inventors:
Matthew Becker, Ennio Tasciotti, Bradley Weiner, Avraam Isayev
Abstract: The present invention relates to a polymer scaffold design and method for treating segmental long bone defects without amputation that permits permanent regrowth of bone in the area of the segmental defect, without external fixation or other problems inherent in current systems. The polymer scaffold is preferably made from a poly(ester urea) polymer and includes an outer shell, sized to fit over a segmental defect in a bone, and a collagen containing material. In some embodiments, the collagen containing material is placed in a polymer insert sized to fit within the segmental bone defect and within said outer shell. In some embodiments, the outer shell may contain struts running longitudinal struts along the inside surface of the outer shell. In some of these embodiments, the insert will have a corresponding set of grooves sized to receive the struts.
Type:
Application
Filed:
May 13, 2015
Publication date:
March 30, 2017
Applicants:
The University of Akron, Houston Methodist Hospital
Inventors:
Matthew Becker, Ennio Tasciotti, Bradley Weiner, Avraam Isayev