Abstract: The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3? of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4? of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
Type:
Grant
Filed:
August 1, 2006
Date of Patent:
July 7, 2009
Assignee:
Houston Pharmaceuticals, Inc.
Inventors:
Waldemar Priebe, Izabella Fokt, Teresa Prezewloka, Marta Krawczyk, Piotr Skibicki, Grzegorz Grynkiewicz, Roman Perez-Soler
Abstract: The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3? of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4? of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
Type:
Application
Filed:
August 1, 2006
Publication date:
February 15, 2007
Applicant:
Houston Pharmaceuticals, Inc.
Inventors:
Waldemar Priebe, Izabella Fokt, Teresa Prezewloka, Marta Krawczyk, Piotr Skibicki, Grzegorz Grynkiewicz, Roman Perez-Soler
Abstract: The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3? of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4? of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
Type:
Grant
Filed:
January 6, 2004
Date of Patent:
September 19, 2006
Assignee:
Houston Pharmaceuticals, Inc.
Inventors:
Waldeman Priebe, Izabella Fokt, Teresa Przewloka, Marta Krawczyk, Piotr Skibicki, Grzegorz Grynkiewicz, Roman Perez-Soler
Abstract: The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
Type:
Grant
Filed:
September 19, 2001
Date of Patent:
January 6, 2004
Assignee:
Houston Pharmaceuticals, Inc.
Inventors:
Waldemar Priebe, Izabella Fokt, Teresa Przewloka, Marta Krawczyk, Piotr Skibicki, Grzegorz Grynkiewicz, Roman Perez-Soler