Patents Assigned to HSC Research & Development Ltd.
  • Patent number: 6307020
    Abstract: A family of related intracellular skin type antifreeze polypeptides and corresponding coding nucleic acids are provided. These are the first skin type intracellular antifreeze polypeptides and coding nucleic acids ever reported. The polypeptides are naturally expressed in the skin of Winter Flounder, and skin specific promoters are also provided. The polypeptides are used to make cells cold-resistant, and to improve the palatability of cold foods and liquids. Cold resistant eukaryotes and prokaryotes, including plants, animals and bacteria are made using the skin-type intracellular antifreeze polypeptides and nucleic acids.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: October 23, 2001
    Assignee: HSC Research and Development Ltd. Partnership
    Inventors: Choy Hew, Zhiyuan Gong
  • Patent number: 5534438
    Abstract: The underlying genetic defect of Huntington disease (HD) has been mapped to chromosomal band 4.sub.p 16.3. Refined localization using recombinant HD chromosome analysis and allelic association analyses have identified two distinct candidate regions. Using a cDNA hybrid selection procedure, .alpha.-adducin has been mapped to the proximal 2.2 Mb 4D gene candidate region within 20 kb of D4S95. Several clones have been mapped within the minimal region containing the HD gene. The clones GT 70 and GT 149 are particularly useful in detecting changes in this portion of the gene of HD patients.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: July 9, 1996
    Assignees: University of British Columbia, HSC Research & Development Ltd.
    Inventors: Michael Hayden, Paul Goldberg, Susan Andrew, Johanna M. Rommens
  • Patent number: 5470709
    Abstract: A method is provided for detecting, ordering and mapping genes or DNA sequences in the genome of eukaryotic cells. The method comprises the steps of releasing free chromatin from the nuclei of the cells and contacting the released free chromatin with at least one detectable probe capable of hybridizing to the genes or DNA sequences to be detected, thereby rendering the genes or DNA sequences detectable.
    Type: Grant
    Filed: September 16, 1993
    Date of Patent: November 28, 1995
    Assignee: HSC Research & Development Ltd. Partnership
    Inventors: Henry H. Q. Heng, Lap-Chee Tsui