Abstract: The present invention relates to an anti-ICAM-1 antibody or an antigen-binding fragment thereof that specifically binds to ICAM-1, and the use thereof. Specifically, provided are an anti-ICAM-1 antibody or an antigen-binding fragment thereof, a pharmaceutical composition for regulating differentiation and/or function of dendritic cell, and a pharmaceutical composition for preventing and/or treating immune cell-mediated disease, the composition comprising the antibody or the antigen-binding fragment as an active ingredient.

Abstract: The present invention relates to an antibody or an antigen-binding fragment thereof specifically binding to CD66c which is expressed in myeloid-derived suppressor cell (MDSC) and a use thereof, and specifically to an antibody or an antigen-binding fragment thereof specifically binding to CD66c, a pharmaceutical composition or a diagnosing composition including the same. The anti-CD66c antibody of the present invention can be used usefully for the treatment of various diseases by targeting MDSC which can induce the immunosuppression.

Abstract: The present invention relates to an anti-CD40 antibody binding specifically to CD40 and use thereof and, particularly, provides an anti-CD40 antibody or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same antibody or fragment as an effective ingredient for prevention and/or treatment of cancer, cancer metastasis, infection, and/or immune deficiency diseases.

Abstract: A near-infrared (NIR) optical shutter comprises a multiple-bandpass filter that is characterized by a bandstop filter region located between first and second bandpass filter regions. The first bandpass filter region passes visible light; the bandstop filter region blocks NIR light of wavelengths within a NIR light sensor band region; and the second bandpass filter region passes NIR light of longer wavelengths than a longer wavelength boundary of the NIR light sensor band region. A polarization state changer positioned between NIR polarizing filters and optically associated with the multiple-bandpass filter causes visible light transmission selectively in first and second light states. The polarization state changer in the first light state causes substantially reduced optical shutter transmission of NIR light in the second bandpass filter region and in the second light state causes substantially increased optical shutter transmission of NIR light in the second bandpass filter region.