Abstract: Disclosed are water soluble effervescent antacid, analgesic powder and tablet formulations which in a preferred embodiment are sodium, sucrose and aspirin free. The formulation is administered through the ingestion of an aqueous solution of the powder or tablet.The powder and tablet formulations of this invention preferably comprise a therapeutically effective amount of acetaminophen as the analgesic and an effective amount of agglomerated particles of an antacid and a food grade acid which will react in an aqueous solution to produce visible gaseous effervescence.The formulations of this invention preferably also comprise flavorants, which improve the taste and lubricants and hardening agents which aid in tableting the formulation.