Patents Assigned to Humab Solutions, Inc.
  • Bifunctional variants of recombinant tissue-type plasminogen activator with platelet aggregation inhibitory activity
    Patent number: 7498410
    Abstract: The present invention provides improved tPA variants having significantly reduced susceptibility to inhibition and increased affinity for platelet integrin as compared with the wild-type tPA. The present invention also provides compositions comprising the tPA variants and polynucleotides, vectors, and host cells for producing the same as well as methods of using these tPA variants to treat disease conditions, e.g., thrombotic disorders.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: March 3, 2009
    Assignee: Humab Solutions, Inc.
    Inventor: Shengfeng Li
  • Bifunctional variants of recombinant tissue-type plasminogen activator with platelet aggregation inhibitory activity
    Publication number: 20070015706
    Abstract: The present invention provides improved tPA variants having significantly reduced susceptibility to inhibition and increased affinity for platelet integrin as compared with the wild-type tPA. The present invention also provides compositions comprising the tPA variants and polynucleotides, vectors, and host cells for producing the same as well as methods of using these tPA variants to treat disease conditions, e.g., thrombotic disorders.
    Type: Application
    Filed: July 18, 2006
    Publication date: January 18, 2007
    Applicant: HuMab Solutions, Inc.
    Inventor: Shengfeng Li