Patents Assigned to Humacyte
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Patent number: 11959060Abstract: Embodiments of the present disclosure are directed to systems, apparatuses, devices and methods for tissue cultivating. Such systems may comprise a plurality of bioreactors, each bioreactor comprising a bag having a mandrel tube arranged therein, and a fluid management system for managing fluid flow among the plurality of bioreactors. The fluid management system can include at least one intra-luminal pump, configured to flow intra-luminal fluid in a first direction in the bioreactors, at least one media pump, configured to flow biomedia fluid in the bioreactors in a second direction opposite to the first direction, and a plurality of valves and/or clamps to effect at least one of filling, flowing, cessation of flow, and draining of at least one of the intra-luminal fluid and biomedia fluid tubes among the bioreactors.Type: GrantFiled: May 15, 2020Date of Patent: April 16, 2024Assignee: HUMACYTE, INC.Inventors: Heather L. Prichard, Dustin Cashman, Joshua McCall, Laura E. Niklason, Benjamin Orbon, Justin T. Strader
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Publication number: 20210246419Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: ApplicationFiled: January 27, 2021Publication date: August 12, 2021Applicant: Humacyte, Inc.Inventors: Shannon L.M. DAHL, Laura E. NIKLASON, Justin T. STRADER, William E. TENTE, Joseph J. LUNDQUIST, Juliana Blum, Heather L. Prichard
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Publication number: 20210236273Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.Type: ApplicationFiled: April 21, 2021Publication date: August 5, 2021Applicants: Humacyte, Inc., Yale UniversityInventors: Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl
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Patent number: 11058534Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.Type: GrantFiled: November 7, 2018Date of Patent: July 13, 2021Assignees: Humacyte, Inc, Yale UniversityInventors: Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl
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Patent number: 10947498Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: GrantFiled: June 13, 2018Date of Patent: March 16, 2021Assignee: humacyte, inc.Inventors: Shannon L. M. Dahl, Laura E. Niklason, Justin T. Strader, William E. Tente, Joseph J. Lundquist
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Patent number: 10934522Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: GrantFiled: May 8, 2018Date of Patent: March 2, 2021Assignee: Humacyte, Inc.Inventors: Shannon L. M. Dahl, Laura E. Niklason, Justin T. Strader, William E. Tente, Joseph J. Lundquist
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Patent number: 10619132Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: GrantFiled: May 15, 2017Date of Patent: April 14, 2020Assignee: Humacyte, Inc.Inventors: Shannon L. M. Dahl, Laura E. Niklason, Justin T. Strader, William E. Tente, Joseph J. Lundquist
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Patent number: 10363124Abstract: Embodiments of the present disclosure are directed to apparatuses and methods for fabricating tubular structures from a combination of fibrous materials for use in, for example, tissue engineering scaffold applications. These materials may also be useful in other biological or non-biological applications in which such tubular fibrous structures may be applicable, examples including conventional medical devices, filters, fiber optics, cable wraps, geotextiles, batteries, fuel cells, armor, and other diverse applications.Type: GrantFiled: September 18, 2015Date of Patent: July 30, 2019Assignee: HUMACYTE, INC.Inventors: George C. Engelmayr, Jr., Laura E. Niklason, Shannon L. Dahl, Justin T. Strader, Jinlin Zhang, Stuart Irwin
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Publication number: 20190069990Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.Type: ApplicationFiled: November 7, 2018Publication date: March 7, 2019Applicants: Humacyte, Inc., Yale UniversityInventors: Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl
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Patent number: 10172707Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.Type: GrantFiled: October 12, 2012Date of Patent: January 8, 2019Assignees: Humacyte, Inc., Yale UniversityInventors: Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl
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Publication number: 20180291333Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: ApplicationFiled: June 13, 2018Publication date: October 11, 2018Applicant: Humacyte, Inc.Inventors: Shannon L.M. DAHL, Laura E. NIKLASON, Justin T. STRADER, William E. TENTE, Joseph J. LUNDQUIST
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Publication number: 20180251727Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: ApplicationFiled: May 8, 2018Publication date: September 6, 2018Applicant: Humacyte, Inc.Inventors: Shannon L.M. DAHL, Laura E. NIKLASON, Justin T. STRADER, William E. TENTE, Joseph J. LUNDQUIST
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Publication number: 20170296323Abstract: Embodiments of the present disclosure are directed to apparatuses and methods for fabricating tubular structures from a combination of fibrous materials for use in, for example, tissue engineering scaffold applications. These materials may also be useful in other biological or non-biological applications in which such tubular fibrous structures may be applicable, examples including conventional medical devices, filters, fiber optics, cable wraps, geotextiles, batteries, fuel cells, armor, and other diverse applications.Type: ApplicationFiled: September 18, 2015Publication date: October 19, 2017Applicant: HUMACYTE, INC.Inventors: George C. ENGELMAYR, JR., Laura E. NIKLASON, Shannon L. DAHL, Justin T. STRADER, Jinlin ZHANG, Stuart IRWIN
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Patent number: 9657265Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: GrantFiled: September 24, 2014Date of Patent: May 23, 2017Assignee: Humacyte, Inc.Inventors: Shannon L. M. Dahl, Laura E. Niklason, Juliana Blum, Justin T. Strader, William E. Tente, Heather L. Prichard, Joseph J. Lundquist
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Patent number: 9650603Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: GrantFiled: September 24, 2014Date of Patent: May 16, 2017Assignee: Humacyte, Inc.Inventors: Shannon L. M. Dahl, Laura E. Niklason, Justin T. Strader, William E. Tente, Joseph J. Lundquist
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Patent number: 9556414Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: GrantFiled: January 6, 2012Date of Patent: January 31, 2017Assignee: HUMACYTEInventors: Shannon L. M. Dahl, Laura E. Niklason, Juliana Blum, Justin T. Strader, William E. Tente, Heather L. Prichard, Joseph J. Lundquist
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Publication number: 20130345824Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: ApplicationFiled: January 6, 2012Publication date: December 26, 2013Applicant: HUMACYTEInventors: Shannon L.M. Dahl, Laura E. Niklason, Juliana Blum, Justin T. Strader, William E. Tente, Heather L. Prichard, Joseph Lundquist
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Publication number: 20130013083Abstract: Constructs including a tubular biodegradable polyglycolic acid scaffold may be coated with extracellular matrix proteins and are substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, an arterial graft, a venous graft, a duct graft, a skin graft, or a urinary graft or conduit.Type: ApplicationFiled: July 5, 2012Publication date: January 10, 2013Applicant: HUMACYTEInventors: Juliana L. BLUM, Shannon L.M. DAHL, Laura E. NIKLASON, Justin T. STRADER, William E. TENTE, Heather L. PRITCHARD, Joseph J. LUNDQUIST
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Publication number: 20120230950Abstract: The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.Type: ApplicationFiled: May 21, 2012Publication date: September 13, 2012Applicant: Humacyte, Inc.Inventors: Laura Niklason, Yuling Li, Juliana Blum, Shannon Dahl, Geoffrey Erickson, Frank Zeigler
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Patent number: 8198245Abstract: The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.Type: GrantFiled: July 24, 2008Date of Patent: June 12, 2012Assignee: Humacyte, Inc.Inventors: Laura Niklason, Yuling Li, Juliana Blum, Shannon Dahl, Geoffrey Erickson, Frank Zeigler