Abstract: A hands-free human-machine interface uses body position, limb motion, speech signals, and/or changes in the operator's level of cognition and/or stress to control the user interface of an interactive system. Signals are acquired from mental and/or physical processes, such as brainwaves, eye, heart, and muscle activities, larynx activity, body position and motion changes, and stress indicating measures. The signals are measured and processed to replace a hand-operated mouse, keypad, joystick, video game, or other controls with a motion-based gestural interface that works, optionally in conjunction with a larynx activated speech processor. For disabled individuals without sufficient dexterity and speech capacity, multimodal neuroanalysis will reveal intended movements and these will be used to operate an imagined mouse or keypad.