Patents Assigned to Human BioSystems
  • Patent number: 7202020
    Abstract: A platelet composition suitable for direct transfusion into a patient is provided. The platelet composition includes a preservation medium comprising plasma and a gel-forming material in a concentration relative to the plasma such that the medium is in a sufficiently fluent state at about 37° C. to allow platelets to move within the medium and is in a sufficiently gelatinous state at about 5° C. to substantially prevent platelets from moving freely within the medium; and platelets.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: April 10, 2007
    Assignee: Human BioSystems
    Inventors: David O. Lucas, Vladamir Serebrennikov
  • Patent number: 7083910
    Abstract: Methods and compositions for preserving blood platelet suspensions which can be stored and preserved for extended periods of time are provided herein. The methods and compositions employ a mixture comprising blood platelets and one or more citrate salts. Such blood platelet mixtures may be cooled either rapidly or slowly and stored for several days prior to use in patients.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: August 1, 2006
    Assignee: Human Biosystems
    Inventors: David Lucas, Raleigh Carmen
  • Publication number: 20060121438
    Abstract: A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium channel blocker, a nucleoside, potassium chloride, polyethylene glycol, at least one amino acid, and a steroid to a temperature of 2° to 4° C. and/or of 0° to 2° C., harvesting a donor organ, perfusing it with one or more of the solution, immersing it in one or more of the solutions and storing it at a temperature above 0° C. or at a temperatures below 0° C. The cryopreservation solution also contains cryopreservative agents. Preserved organs may be transplanted directly from refrigeration storage or from freezer storage by cooling the washing refrigeration preservation solutions to 2° to 4° C., perfusing the organ with washing solution and then preservation solution, and transplanting it.
    Type: Application
    Filed: February 16, 2006
    Publication date: June 8, 2006
    Applicant: Human BioSystems
    Inventors: Luis Toledo-Pereyra, Fernando Lopez-Neblina
  • Patent number: 7029839
    Abstract: A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium channel blocker, a nucleoside, potassium chloride, polyethylene glycol, at least one amino acid, and a steroid to a temperature of 2° to 4° C. and/or of 0° to 2° C., harvesting a donor organ, perfusing it with one or more of the solution, immersing it in one or more of the solutions and storing it at a temperature above 0° C. or at a temperatures below 0° C. The cryopreservation solution also contains cryopreservative agents. Preserved organs may be transplanted directly from refrigeration storage or from freezer storage by cooling the washing refrigeration preservation solutions to 2° to 4° C., perfusing the organ with washing solution and then preservation solution, and transplanting it.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: April 18, 2006
    Assignee: Human BioSystems
    Inventors: Luis H. Toledo-Pereyra, Fernando Lopez-Neblina
  • Publication number: 20050019917
    Abstract: A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium channel blocker, a nucleoside, potassium chloride, polyethylene glycol, at least one amino acid, and a steroid to a temperature of 2° to 4° C. and/or of 0° to 2° C., harvesting a donor organ, perfusing it with one or more of the solution, immersing it in one or more of the solutions and storing it at a temperature above 0° C. or at a temperatures below 0° C. The cryopreservation solution also contains cryopreservative agents. Preserved organs may be transplanted directly from refrigeration storage or from freezer storage by cooling the washing refrigeration preservation solutions to 2° to 4° C., perfusing the organ with washing solution and then preservation solution, and transplanting it.
    Type: Application
    Filed: April 22, 2004
    Publication date: January 27, 2005
    Applicant: Human BioSystems
    Inventors: Luis Toledo-Pereyra, Fernando Lopez-Neblina
  • Patent number: 6828090
    Abstract: A platelet composition suitable for direct transfusion into a patient is provided. The platelet composition includes a preservation medium comprising plasma and a gel-forming material in a concentration relative to the plasma such that the medium is in a sufficiently fluent state at about 37° C. to allow platelets to move within the medium and is in a sufficiently gelatinous state at about 5° C. to substantially prevent platelets from moving freely within the medium; and platelets.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: December 7, 2004
    Assignee: Human BioSystems
    Inventors: David O. Lucas, Vladimir Serebrennikov