Patents Assigned to Human Matrix Sciences, LLC
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Publication number: 20190153045Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: ApplicationFiled: November 27, 2018Publication date: May 23, 2019Applicants: HUMAN MATRIX SCIENCES, LLC, THE HOSPITAL FOR SICK CHILDRENInventors: Felipe Jimenez, Thomas Mitts, Aleksander Hinek
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Patent number: 10167325Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: GrantFiled: June 20, 2016Date of Patent: January 1, 2019Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Felipe Jimenez, Thomas Mitts, Aleksander Hinek
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Patent number: 9867804Abstract: Embodiments provide methods for using ascorbate for the stimulation of production of elastic fibers by cells.Type: GrantFiled: June 28, 2016Date of Patent: January 16, 2018Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Thomas F. Mitts, Aleksander Hinek, Hyunjun Jonathan Kim
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Publication number: 20170002047Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: ApplicationFiled: June 20, 2016Publication date: January 5, 2017Applicants: HUMAN MATRIX SCIENCES, LLC, THE HOSPITAL FOR SICK CHILDRENInventors: Felipe JIMENEZ, Thomas MITTS, Aleksander HINEK
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Patent number: 9492462Abstract: Compositions and methods for inducing the deposition of elastin in skin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.Type: GrantFiled: June 21, 2013Date of Patent: November 15, 2016Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Aleksander Hinek, Thomas Mitts
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Publication number: 20160303071Abstract: Embodiments provide methods for using ascorbate for the stimulation of production of elastic fibers by cells.Type: ApplicationFiled: June 28, 2016Publication date: October 20, 2016Applicants: HUMAN MATRIX SCIENCES, LLC, THE HOSPITAL FOR SICK CHILDRENInventors: Thomas F. MITTS, Aleksander HINEK, Hyunjun Jonathan KIM
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Patent number: 9458197Abstract: The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of Elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of Elastin that penetrate into the tissue to which it is applied. The present invention describes compositions containing an elastin digest derived from proteolytic digestion of insoluble elastin derived from mammalian ligaments with a protein digesting composition, such as proteinase K. The elastin digest is a mixture of elastin peptides wherein the elastin peptide mixture comprises peptides of the sequence GXXPG, wherein X represents one of the natural amino acids. The elastin digest of the present invention may also comprise epitopes of cytokines, growth factors and di-peptides.Type: GrantFiled: September 8, 2014Date of Patent: October 4, 2016Assignee: Human Matrix Sciences, LLCInventors: Thomas Mitts, Felipe Jimenez
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Patent number: 9422334Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: GrantFiled: August 26, 2013Date of Patent: August 23, 2016Assignees: The Hospital For Sick Children, Human Matrix Sciences, LLCInventors: Felipe Jimenez, Thomas Mitts, Aleksander Hinek
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Patent number: 9387194Abstract: Embodiments provide methods for using ascorbate for the stimulation of production of elastic fibers by cells.Type: GrantFiled: January 18, 2013Date of Patent: July 12, 2016Assignees: Human Matrix Sciences, LLC, The Hospital For Sick ChildrenInventors: Thomas F. Mitts, Aleksander Hinek, Hyunjun Jonathan Kim
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Patent number: 9283236Abstract: Compositions and methods for inducing the deposition of elastin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.Type: GrantFiled: October 18, 2013Date of Patent: March 15, 2016Assignees: The Hospital for Sick Children, Human Matrix Sciences, LLCInventors: Aleksander Hinek, Thomas F. Mitts
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Patent number: 9254300Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.Type: GrantFiled: January 8, 2014Date of Patent: February 9, 2016Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Thomas Mitts, Felipe Jimenez, Aleksander Hinek
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Publication number: 20150359854Abstract: Compositions and methods for modulating the deposition of elastin by administering compositions including insulin receptor agonists are described herein.Type: ApplicationFiled: June 8, 2015Publication date: December 17, 2015Applicants: THE HOSPITAL FOR SICK CHILDREN, HUMAN MATRIX SCIENCES, LLCInventors: Thomas F. MITTS, Aleksander HINEK
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Patent number: 9006170Abstract: The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereof, suitable in facilitating synthesis and deposition of connective tissue matrix, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferation of these cell types. The present invention also describes methods of treatment of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.Type: GrantFiled: January 12, 2010Date of Patent: April 14, 2015Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Thomas Mitts, Felipe Jimenez, Aleksander Hinek, Severa Bunda
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Patent number: 8871707Abstract: The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides. The invention further comprises cosmetic and pharmaceutical treatment methods using the therapeutic fibroblast compositions of the invention.Type: GrantFiled: September 16, 2010Date of Patent: October 28, 2014Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Felipe Jimenez, Thomas F. Mitts, Aleksander Hinek
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Patent number: 8828927Abstract: The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of Elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of Elastin that penetrate into the tissue to which it is applied. The present invention describes compositions containing an elastin digest derived from proteolytic digestion of insoluble elastin derived from mammalian ligaments with a protein digesting composition, such as proteinase K. The elastin digest is a mixture of elastin peptides wherein the elastin peptide mixture comprises peptides of the sequence GXXPG, wherein X represents one of the natural amino acids. The elastin digest of the present invention may also comprise epitopes of cytokines, growth factors and di-peptides.Type: GrantFiled: June 10, 2013Date of Patent: September 9, 2014Assignee: Human Matrix Sciences, LLCInventors: Thomas Mitts, Felipe Jimenez
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Publication number: 20140155335Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.Type: ApplicationFiled: January 8, 2014Publication date: June 5, 2014Applicants: THE HOSPITAL FOR SICK CHILDREN, HUMAN MATRIX SCIENCES, LLCInventors: Thomas MITTS, Felipe JIMENEZ, Aleksander HINEK
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Publication number: 20140100170Abstract: The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.Type: ApplicationFiled: August 26, 2013Publication date: April 10, 2014Applicants: THE HOSPITAL FOR SICK CHILDREN, HUMAN MATRIX SCIENCES, LLCInventors: Felipe JIMENEZ, Thomas MITTS, Aleksander HINEK
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Publication number: 20140065635Abstract: Various methods of assessing the regenerative potential of dermal tissue in a patient may be determined and methods to determine the potential development of stretch marks in a patient are provided. Through the analysis of a series of dermal tissue samples, a method of monitoring the aging process of the dermal tissue of a patient is possible. Damaged or stretched marked skin may also be used in the development of various diagnostic therapies relating to the inducement of the extracellular matrix components of the skin due to the loss of elastic fibers generally found in stretch marked skin.Type: ApplicationFiled: July 30, 2013Publication date: March 6, 2014Applicants: THE HOSPITAL FOR SICK CHILDREN, HUMAN MATRIX SCIENCES, LLCInventors: Thomas MITTS, Felipe JIMENEZ, Aleksander HINEK
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Publication number: 20140056916Abstract: Compositions and methods for inducing the deposition of elastin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.Type: ApplicationFiled: October 18, 2013Publication date: February 27, 2014Applicants: THE HOSPITAL FOR SICK CHILDREN, HUMAN MATRIX SCIENCES, LLCInventors: Aleksander HINEK, Thomas F. MITTS
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Patent number: 8642578Abstract: Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.Type: GrantFiled: October 25, 2007Date of Patent: February 4, 2014Assignees: Human Matrix Sciences, LLC, The Hospital for Sick ChildrenInventors: Thomas Mitts, Felipe Jimenez, Aleksander Hinek