Abstract: Provided are a novel compound that effectively antagonizes P2X3 receptor, a preparation method thereof, and use thereof in the preparation of drugs. The compound is a compound represented by Formula I, or a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof.
Type:
Application
Filed:
March 28, 2023
Publication date:
July 20, 2023
Applicants:
HUMANWELL HEALTHCARE (GROUP) CO., LTD., WUHAN HUMANWELL INNOVATIVE DRUG RESEARCH AND DEVELOPMENT CENTER LIMITED COMPANY
Inventors:
Xuejun ZHANG, Yang ZANG, Xueqiang LI, Chengbing YANG, Yonggang WANG, Bo ZHANG, Yang LI, Lifei LIU, Jun YANG, Lie LI
Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof. The 4H-pyrazolo[1,5-alpha]benzimidazole compound has the structure of Compound 2.
Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1,5-alpha]benzimidazole compound and a preparation method and intermediate thereof.
Abstract: Disclosed is a series of analogs of 4H-pyrazolo[1,5-?]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound as shown by formula (I) or a pharmaceutically acceptable salt thereof as a PARP inhibitor.
Type:
Grant
Filed:
March 30, 2015
Date of Patent:
January 2, 2018
Assignees:
Hubei Bio-Pharmaceutical Industrial Technological Institute Inc., Humanwell Healthcare (Group) Co., Ltd., Medshine Discovery Inc.
Inventors:
Xuehai Wang, Zhaozhong Ding, Yong Xu, Shuhui Chen, Lie Li, Gang Li, Ronghua Tu, Cailin Wang, Yang Yue, Zhibo Zhang, Hailiang Chen, Wenjie Sun, Lu Huang
Abstract: A capsule containing total flavonoids of Desmodium styracifolium, a method for preparing the same and a use of the capsule containing total flavonoids of Desmodium styracifolium are provided. Specifically, the capsule includes total flavonoids of Desmodium Styracifolium provided in a form of alcohol extract of Desmodium Styracifolium and a pharmaceutically acceptable excipient.
Type:
Grant
Filed:
July 15, 2014
Date of Patent:
August 8, 2017
Assignees:
HUMANWELL HEALTHCARE (GROUP) CO., LTD., WUHAN OPTICS VALLEY HUMANWELL BIO-PHARMACEUTICAL CO., LTD., HUBEI BIOLOGICAL MEDICINE INDUSTRIAL TECHNOLOGY INSTITUTE CO., LTD., WUHAN CHEMLIGAND BIO-PHARMACEUTICAL CO., LTD.
Inventors:
Xuehai Wang, Yong Xu, Li'e Li, Jie Li, Ronghua Tu, Gang Chen, Rubin Cao, Yun Feng, Zhongwen Yang, Zhaoze Fan, Yanping Yu, Qiang Xiao, Lu Huang, Chengbing Yang, Tianci Huang, Hua Tian, Jing Yang