Patents Assigned to Hunan Rivers Biotechnology Co. Ltd.
  • Methods and genetically engineered micro-organisms for the combined production of PDO, BDO and PHP by fermentation
    Patent number: 8507250
    Abstract: The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: August 13, 2013
    Assignees: Tsinghua University, Hunan Rivers Biotechnology Co. Ltd.
    Inventors: Dehua Liu, Hongjuan Liu, Xianjin Ou, Yan Sun, Yunzhen Xu, Yueyong Lei, Weibin Liu
  • METHODS AND GENETICALLY ENGINEERED MICRO-ORGANISMS FOR THE COMBINED PRODUCTION OF PDO, BDO AND PHP BY FERMENTATION
    Publication number: 20120258521
    Abstract: The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught.
    Type: Application
    Filed: June 20, 2012
    Publication date: October 11, 2012
    Applicants: HUNAN RIVERS BIOTECHNOLOGY CO. LTD., TSINGHUA UNIVERSITY
    Inventors: Dehua LIU, Hongjuan LIU, Xianjin OU, Yan SUN, Yunzhen XU, Yueyong LEI, Weibin LIU
  • Methods and genetically engineered micro-organisms for the combined production of PDO, BDO and PHP by fermentation
    Patent number: 8227217
    Abstract: The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: July 24, 2012
    Assignees: Tsinghua University, Hunan Rivers Biotechnology Co. Ltd.
    Inventors: Dehua Liu, Hongjuan Liu, Xianjin Ou, Yan Sun, Yunzhen Xu, Yueyong Lei, Weibin Liu
  • METHODS AND GENETICALLY ENGINEERED MICRO-ORGANISMS FOR THE COMBINED PRODUCTION OF PDO, BDO AND PHP BY FERMENTATION
    Publication number: 20110117617
    Abstract: The present invention relates to methods and genetically engineered micro-organisms for the combined production of PDO, BDO, and PHP by fermentation. The micro-organism is characterized in that its D-lactate dehydrogenase gene has been deleted or functionally inactivated, and it comprises heterogenous polynucleotides encoding the Coenzyme A-dependent Aldehyde dehydrogenase and the Polyhydroxyalkanoate synthase.
    Type: Application
    Filed: November 17, 2009
    Publication date: May 19, 2011
    Applicants: TSINGHUA UNIVERSITY, HUNAN RIVERS BIOTECHNOLOGY CO. LTD.
    Inventors: Dehua LIU, Hongjuan LIU, Xianjin OU, Yan Sun, Yunzhen Xu, Yueyong LEI, Weibin LIU