Patents Assigned to HUREL CORPORATION
  • METHODS FOR CHARACTERIZING TIME-BASED HEPATOTOXICITY
    Publication number: 20180113119
    Abstract: Methods of characterizing the time-based hepatotoxicity of a test compound are provided. In some embodiments the provided methods allow prediction of the hepatotoxic potential of a test compound in a way that is improved relative to that achievable with prior art methods. In some embodiments the methods may be used to quantify the relationship between measurements or estimates of toxicity made at different, successive points in time, to provide highly meaningful tool to assess the likely in vivo hepatotoxicity of test compounds in vivo.
    Type: Application
    Filed: March 21, 2016
    Publication date: April 26, 2018
    Applicant: HUREL CORPORATION
    Inventors: Robert FREEDMAN, James MACDONALD, Eric NOVIK
  • PRIMARY MAMMALIAN CELL CULTURE SYSTEMS AND METHODS
    Publication number: 20170260490
    Abstract: Primary mammalian cell culture systems, methods of making primary mammalian cell culture systems, and methods of culturing primary mammalian cells are provided. In some embodiments the systems and methods utilize an exothermic chemical process as a heat source for culturing and shipping cultures comprising primary mammalian cells.
    Type: Application
    Filed: August 19, 2015
    Publication date: September 14, 2017
    Applicant: HUREL CORPORATION
    Inventors: Erik NOVIK, Amit PAREKH, Eric PLUDWINSKI, Anil SHRIRAO
  • COMPOSITIONS AND METHODS OF FUNCTIONALLY ENHANCED IN VITRO CELL CULTURE SYSTEM
    Publication number: 20160137984
    Abstract: Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture.
    Type: Application
    Filed: January 20, 2016
    Publication date: May 19, 2016
    Applicants: HUREL CORPORATION, GENERAL HOSPITAL CORPORATION
    Inventors: Martin Yarmush, Robert Freedman, Yaakov Nahmias, Eric Novik
  • Compositions and methods of functionally enhanced in vitro cell culture system
    Patent number: 9243221
    Abstract: Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: January 26, 2016
    Assignees: HUREL CORPORATION, THE GENERAL HOSPITAL CORPORATION
    Inventors: Martin Yarmush, Robert Freedman, Yaakov Nahmias, Eric Novik
  • COMPOSITIONS AND METHODS OF FUNCTIONALLY ENHANCED IN VITRO CELL CULTURE SYSTEM
    Publication number: 20120129207
    Abstract: Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture.
    Type: Application
    Filed: November 24, 2009
    Publication date: May 24, 2012
    Applicants: THE GENERAL HOSPITAL CORPORATION, HUREL CORPORATION
    Inventors: Martin Yarmush, Robert Freedman, Yaakov Nahmias, Erik Novik