Abstract: A disposable tip adapted for use in connection with an optical probe of an instrument. The tip includes a one-piece molded elastomeric base member having a boot and an opaque tissue-engaging surface. The boot releasably mates with and provides an interference/friction fit to the probe. The tissue-engaging surface surrounds and extends from the boot. A window in the base member extends into the boot to transmit light between the probe and tissue. A layer of optically transparent material covers the window on the tissue-engaging surface. Adhesive on the tissue-engaging surface of the base member releasably secures the probe to the tissue being analyzed.