Abstract: The present invention relates to functionalized saccharides anti-inflammatory agents which acts upon inflammatory mechanisms in mammals, in particular anti-inflammatory agents which act upon the expression of at least one cytokine by suppressing or inhibiting the expression of the at least one cytokine wherein said cytokine is selected from the group consisting of pro-inflammatory cytokines, anti-inflammatory cytokines and chemokines.
Abstract: Compositions are provided that contain sporulated coccidial oocysts, wherein the compositions are free of antibiotics and comprise formalin at a concentration sufficient to inhibit microbial growth for at least 12 months while maintaining oocyst viability. Methods of preparing such compositions are also provided.
Type:
Grant
Filed:
July 2, 2021
Date of Patent:
July 4, 2023
Assignee:
Huvepharma Inc.
Inventors:
Mary Ann Pfannenstiel, Jennifer Albrecht, Glen M. Wilkinson
Abstract: The present invention relates to new uses and methods of treatment. Specifically, the invention relates to new uses of Avermectins such as ivermectin for the treatment of Coronaviridae infection such as MERS, SARS or COVID-19 infection. In particular, the invention relates to new uses of Avermectins such as ivermectin for the treatment of COVID-19 infection.
Type:
Application
Filed:
May 21, 2021
Publication date:
April 13, 2023
Applicant:
Huvepharma EOOD
Inventors:
Kiril Petrov Domuschiev, Georgi Petrov Domuschiev
Abstract: The present invention provides phytase enzymes exhibiting a surprisingly high thermostability as compared to commercially available phytases. Additionally some of the new phytase variants display up to four fold increased catalytic rate thus greatly increased speed of phytate dephosphorilation.
Type:
Grant
Filed:
September 6, 2018
Date of Patent:
February 8, 2022
Assignee:
HUVEPHARMA EOOD
Inventors:
Spas Bojidarov Petkov, Nikolay Stoyanov Outchkourov
Abstract: The present disclosure provides for an adjuvant composition that is suited for injectable as well as transdermal administration. The adjuvant composition generally comprises a lipophile, a polymer of acrylic or methacrylic acid, saline, cholesterol, a saponin, and sodium hydroxide. A vaccine composition is also provided for that generally includes the vaccine composition of the present disclosure and an antigen. A method for vaccinating animals and humans utilizing the adjuvant composition of the present disclosure is also provided.
Type:
Grant
Filed:
February 4, 2019
Date of Patent:
October 26, 2021
Assignee:
Huvepharma, Inc.
Inventors:
Timothy J. Miller, Mary Ann Pfannenstiel
Abstract: Compositions are provided that contain sporulated coccidial oocysts, wherein the compositions are free of antibiotics and comprise formalin at a concentration sufficient to inhibit microbial growth for at least 12 months while maintaining oocyst viability. Methods of preparing such compositions are also provided.
Type:
Grant
Filed:
August 26, 2019
Date of Patent:
September 22, 2020
Assignee:
HUVEPHARMA, INC.
Inventors:
Mary Ann Pfannenstiel, Jennifer Albrecht, Glen M. Wilkinson
Abstract: The present invention relates to functionalized saccharides anti-inflammatory agents which acts upon inflammatory mechanisms in mammals, in particular anti-inflammatory agents which act upon the expression of at least one cytokine by suppressing or inhibiting the expression of the at least one cytokine wherein said cytokine is selected from the group consisting of pro-inflammatory cytokines, anti-inflammatory cytokines and chemokines.
Abstract: A method is described for improving the nutritional value of a foodstuff comprising a source of myo-inositol hexakisphosphate by feeding the foodstuff in combination with a phytase expressed in yeast. The method comprises the step of feeding the animal the foodstuff in combination with a phytase expressed in yeast wherein the phytase can be selected from the group consisting of AppA1, AppA2 and a site-directed mutant of AppA. The invention also enables reduction of the feed to weight gain ratio and an increase bone mass and mineral content of an animal. A foodstuff and a feed additive comprising AppA2 or a site-directed mutant of AppA are also described.
Type:
Grant
Filed:
June 7, 2011
Date of Patent:
October 8, 2013
Assignees:
Huvepharma AD, Cornell Research Foundation, Inc.
Inventors:
Douglas M. Webel, Donald E. Orr, Frank E. Ruch, Xingen Lei
Abstract: Disclosed is the continuous supplementation of poultry feeding stuffs with paromomycin and the resulting effects of prophylaxis against histomoniasis, ensuing decrease of mortality and the reduction of horizontal spreading of the disease. Also observed are improved zoo-technical performances, increase in weight gain and feed efficiency, both in healthy as well as diseased birds.
Abstract: Disclosed is the continuous supplementation of poultry feeding stuffs with paromomycin and the resulting effects of prophylaxis against histomoniasis, ensuing decrease of mortality and the reduction of horizontal spreading of the disease. Also observed are improved zoo-technical performances, increase in weight gain and feed efficiency, both in healthy as well as diseased birds.