Patents Assigned to Hybrigen, Inc.
  • Adjustable sensitivity, genetic molecular interaction systems, including protein-protein interaction systems for detection and analysis
    Patent number: 6790607
    Abstract: A method for detecting interactions between first and second interacting molecules at variable sensitivity. This variable sensitivity may be obtained by providing for the overexpression of either a bait hybrid protein containing a DNA binding domain (desensitization) or a prey hybrid protein containing the DNA activation domain for a reporter gene (enhanced sensitivity). The use of exogenous activators of one or the other according to the needs of a particular system is readily accomplished.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: September 14, 2004
    Assignee: Hybrigen, Inc.
    Inventors: David N. Edwards, Arlene Leon, David F. Ranney