Abstract: The present invention relates to protein-protein interactions of adipocytes, e.g., complexes of such polypeptides, polynucleotides encoding the polypeptides and complexes thereof, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that modulate the protein-protein interactions.

Abstract: The present invention relates to protein-protein interactions involved in deafness or in hearing disorders and/or diseases. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.