Abstract: An insertion tool having a wall of tubular or funneled shape, with, on a front portion thereof, a front side opening so that an opening of an empty pouch for an implantable pulse generator, and corresponding wiring, can be shifted onto the front portion and over the front side opening, and with, on a back portion of the insertion tool, a backside opening so that an implantable pulse generator, and corresponding wiring, can be inserted through that backside opening, through a passageway opening to the front side opening and into the pouch, while manually holding the insertion tool using the back portion The wall has an axial slot between the front side opening and the backside opening.

Abstract: Device for sustained controlled release of therapeutically active substance after implantation of the device alone or in combination with further implantable elements. The device has one layer of material having at least one therapeutically active substance, wherein the layer has a biodegradable matrix consisting of a mixture of 60-95% by dry weight of a first component (A) in the form of a copolymer of DL-lactide and glycolide (PLGA) with a molar ratio of DL-lactide to glycolide in the range of 40:60-60:40 and with a weight average molecular weight (MWw) in the range of 100,000-150,000 g/mol and 5-40% by dry weight of a second component (B) in the form of polyethylene glycol (PEG), the dry weights of component (A) and (B) complementing to 100% of the matrix. In this matrix the at least one therapeutically active substance is dissolved and/or suspended.

Abstract: Method for the preparation of an implantable device, wherein in a first step a non-degradable implantable device is at least partially covered or surrounded by at least one separate layer of material comprising a therapeutically active substance providing for sustained controlled release of said substance under physiological conditions, and wherein in a second step this is inserted into a wet or humid pouch through an opening thereof.

Abstract: An insertion tool having a wall of tubular or funnelled shape, with, on a front portion thereof, a front side opening so that an opening of an empty pouch for an implantable pulse generator, and corresponding wiring, can be shifted onto the front portion and over the front side opening, and with, on a back portion of the insertion tool, a backside opening so that an implantable pulse generator, and corresponding wiring, can be inserted through that backside opening, through a passageway opening to the front side opening and into the pouch, while manually holding the insertion tool using the back portion The wall has an axial slot between the front side opening and the backside opening.