Abstract: Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine.

Abstract: Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy.

Abstract: Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy. Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine. The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.

Abstract: An improved precision diluter/dispenser device is provided with features for effecting automatic compensation for non-linearity of aspirated fluid volumes of the particular piston and cylinder syringe assemblies that are included with the diluter/dispenser device in order to enhance the accuracy of the device by varying the piston stroke length in order to correct for non-linearity of aspirated or dispensed fluid volumes. Suitable correction factors are programmed into the control mechanism of the device in order to automatically make the necessary adjustments in stroke length so as to significantly enhance the linearity of the movement of fluid volumes throughout the working volume of the piston and cylinder assembly, whether the movement of fluid be of a very small percentage or a very large percentage of the volume capacity of the assembly.

Abstract: The flow monitoring device comprises a housing having a passageway therethrough for liquid flow through the housing. The passageway has an inlet opening and an outlet opening. A first thermistor is provided for sensing the temperature of the liquid in the passageway at a place near the inlet opening. A heating resistor is provided for heating the liquid at a place near the outlet opening and a second thermistor is provided for sensing the temperature of the liquid at the place near the outlet opening. A control circuit controls the input of heat energy to the heating resistor for heating the liquid just enough to maintain a predetermined temperature differential between the first and second thermistors.