Abstract: An earpiece-oriented sterilizing dustproof device includes an earpiece rack body, two swing door bodies, a casing, and a sterilization light source module. The earpiece rack body comprises an upper base, a lower base, and a connection element. The connection element is disposed between the upper base and the lower base. The upper base, the lower base and the connection element define a receiving space. The swing door bodies are pivotally connected to two ends of the earpiece rack body, respectively. The swing door bodies conceal the receiving space. The casing is disposed on the lower base and has two opposing transparent oblique surfaces corresponding in position to the swing door bodies, respectively. The sterilization light source module is disposed at the lower base and inside the casing. Therefore, the earpiece-oriented sterilizing dustproof device is dustproof and disinfects ear pads of on-ear earpieces.