Patents Assigned to HYPHA DISCOVERY LTD.
  • CYTOCHROME P450 ENZYME
    Publication number: 20240263208
    Abstract: The invention provides an enzyme with cytochrome P450 activity with mutations at the 109 and/or 198 positions based on P450SeuC10 from Streptomyces eurythermus NRRL 2539. The invention extends to related nucleic acid material and microorganisms, kits containing the enzyme, methods of producing the enzyme and methods of using the enzyme to generate oxidised organic compounds.
    Type: Application
    Filed: May 26, 2022
    Publication date: August 8, 2024
    Applicant: HYPHA DISCOVERY LTD.
    Inventors: Jonathan STEELE, Vincent POON, Stephen WRIGLEY, Emily HOPKINS, Aksana KHAN
  • Hydroxylation techniques
    Patent number: 11618906
    Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: April 4, 2023
    Assignee: HYPHA DISCOVERY LTD.
    Inventors: Jonathan Charles Paul Steele, Antonio De Riso, Francesco Falcioni, Richard Kerry Phipps, Stephen Keith Wrigley, Kinga Linda Nytko, Vincent Poon, Sebastian Schulz, John Maxim Ward, Mariacristina Bawn
  • HYDROXYLATION TECHNIQUES
    Publication number: 20210230642
    Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.
    Type: Application
    Filed: May 14, 2019
    Publication date: July 29, 2021
    Applicant: HYPHA DISCOVERY LTD.
    Inventors: Jonathan Charles Paul STEELE, Antonio DE RISO, Francesco FALCIONI, Richard Kerry PHIPPS, Stephen Keith WRIGLEY, Kinga Linda NYTKO, Vincent POON, Sebastian SCHULZ, John Maxim WARD, Mariacristina BAWN